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Expression of DNAM-1 (CD226) on inflammatory monocytes
http://hdl.handle.net/2241/00137290
http://hdl.handle.net/2241/00137290226379c1-37ca-4a3c-875b-46908e4d68c8
名前 / ファイル | ライセンス | アクション |
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MI_69 (3.9 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2016-03-15 | |||||
タイトル | ||||||
タイトル | Expression of DNAM-1 (CD226) on inflammatory monocytes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Anh Van Vo
× Anh Van Vo× Takenaka, Eri× Shibuya, Akira× Shibuya, Kazuko |
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著者別名 |
渋谷, 彰
× 渋谷, 彰× 渋谷, 和子 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | DNAM-1 is an activating receptor expressed on NK cells and T cells and plays an important role in cytotoxicity of these cells against target cells. Although the role of DNAM-1 in the function of T cells and NK cells has been well studied, the expression and function of DNAM-1 on myeloid cells have been incompletely understood. In this study, we investigated expression of DNAM-1 on monocyte subsets in mouse peripheral blood and found that only inflammatory monocytes (iMos), but not patrolling monocytes (pMos), expressed high levels of DNAM-1. In addition, we found that DNAM-1 was highly expressed on iMos, rather than pMos, also in human. Furthermore, we found that DNAM-1 on inflammatory monocytes was involved in cell adhesion to CD155-expressing cells. Therefore, we propose that expression of DNAM-1 on inflammatory monocytes are evolutionally conserved and act as an adhesion molecule on blood inflammatory monocytes. | |||||
書誌情報 |
Molecular immunology 巻 69, p. 70-76, 発行日 2016-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0161-5890 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00307483 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 26675069 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.molimm.2015.11.009 | |||||
権利 | ||||||
権利情報 | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier |