{"created":"2021-03-01T07:16:30.455378+00:00","id":37398,"links":{},"metadata":{"_buckets":{"deposit":"03f1e452-1692-4d27-b194-fe0f482bedff"},"_deposit":{"id":"37398","owners":[],"pid":{"revision_id":0,"type":"depid","value":"37398"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00037398","sets":["2780:987","3:62:5595:431","7131:543"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"76","bibliographicPageStart":"70","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"Molecular immunology"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渋谷, 彰"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"渋谷, 和子"}],"nameIdentifiers":[{},{},{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"DNAM-1 is an activating receptor expressed on NK cells and T cells and plays an important role in cytotoxicity of these cells against target cells. Although the role of DNAM-1 in the function of T cells and NK cells has been well studied, the expression and function of DNAM-1 on myeloid cells have been incompletely understood. In this study, we investigated expression of DNAM-1 on monocyte subsets in mouse peripheral blood and found that only inflammatory monocytes (iMos), but not patrolling monocytes (pMos), expressed high levels of DNAM-1. In addition, we found that DNAM-1 was highly expressed on iMos, rather than pMos, also in human. Furthermore, we found that DNAM-1 on inflammatory monocytes was involved in cell adhesion to CD155-expressing cells. Therefore, we propose that expression of DNAM-1 on inflammatory monocytes are evolutionally conserved and act as an adhesion molecule on blood inflammatory monocytes.","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26675069","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.molimm.2015.11.009","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0161-5890","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00307483","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Anh Van Vo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takenaka, Eri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibuya, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibuya, Kazuko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-01"}],"displaytype":"detail","filename":"MI_69.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"MI_69","url":"https://tsukuba.repo.nii.ac.jp/record/37398/files/MI_69.pdf"},"version_id":"fb60ef38-9eef-43af-96b5-10bd39d3f6ab"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of DNAM-1 (CD226) on inflammatory monocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of DNAM-1 (CD226) on inflammatory monocytes"}]},"item_type_id":"5","owner":"1","path":["543","987","431"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-15"},"publish_date":"2016-03-15","publish_status":"0","recid":"37398","relation_version_is_last":true,"title":["Expression of DNAM-1 (CD226) on inflammatory monocytes"],"weko_creator_id":"1","weko_shared_id":5},"updated":"2022-04-27T09:06:56.685545+00:00"}