WEKO3
アイテム
Physical and Functional Association of LFA-1 with DNAM-1 Adhesion Molecule
http://hdl.handle.net/2241/102003
http://hdl.handle.net/2241/1020039bf39b74-30f4-4f32-825c-31080d690405
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Immunity_11-5.pdf (97.5 kB)
|
|
|
|
Immunity_11-5Figs.pdf (141.8 kB)
|
|
| Item type | Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-03-25 | |||||
| タイトル | ||||||
| タイトル | Physical and Functional Association of LFA-1 with DNAM-1 Adhesion Molecule | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
渋谷, 和子
× 渋谷, 和子× Lanier, Lewis L.× Phillips, Joseph H.× Ochs, Hans D.× Shimizu, Kenji× Nakayama, Eiichi× Nakauchi, Hiromitsu× 渋谷, 彰 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Whereas ligation of the DNAM-1 adhesion molecule triggers cytotoxicity mediated by normal NK and T cells, this function was defective in NK cell clones from leukocyte adhesion deficiency syndrome. However, genetic reconstitution of cell surface expression of LFA-1 restored the ability of DNAM-1 to initiate anti-DNAM-1 mAb-induced cytotoxicity, indicating a functional relationship between DNAM-1 and LFA-1. Further studies demonstrated that LFA-1 physically associates with DNAM-1 in NK cells and anti-CD3 mAb stimulated T cells, for which serine phosphorylation of DNAM-1 plays a critical role. In addition, crosslinking of LFA-1 induces tyrosine phosphorylation of DNAM-1, for which the Fyn protein tyrosine kinase is responsible. These results indicate that DNAM-1 is involved in the LFA-1-mediated intracellular signals. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Immunity 巻 11, 号 5, p. 615-623, 発行日 1999-11 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1074-7613 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11006671 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/S1074-7613(00)80136-3 | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 10591186 | |||||
| 権利情報 | ||||||
| 言語 | en | |||||
| 権利情報 | © 1999 by Cell Press | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 出版者 | ||||||
| 出版者 | Elsevier (Cell Press) | |||||
| 言語 | en | |||||
