{"created":"2021-03-01T06:54:47.162920+00:00","id":17546,"links":{},"metadata":{"_buckets":{"deposit":"48835c32-68f7-4147-bf07-1e8ce5ea210e"},"_deposit":{"id":"17546","owners":[],"pid":{"revision_id":0,"type":"depid","value":"17546"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00017546","sets":["2780:987","3:62:5591:604","7131:543"]},"author_link":["515","62276","62277","62278","62279","62280","62281","117"],"control_number":"17546","item_1644910766877":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"623","bibliographicPageStart":"615","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Immunity","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Whereas ligation of the DNAM-1 adhesion molecule triggers cytotoxicity mediated by normal NK and T cells, this function was defective in NK cell clones from leukocyte adhesion deficiency syndrome. However, genetic reconstitution of cell surface expression of LFA-1 restored the ability of DNAM-1 to initiate anti-DNAM-1 mAb-induced cytotoxicity, indicating a functional relationship between DNAM-1 and LFA-1. Further studies demonstrated that LFA-1 physically associates with DNAM-1 in NK cells and anti-CD3 mAb stimulated T cells, for which serine phosphorylation of DNAM-1 plays a critical role. In addition, crosslinking of LFA-1 induces tyrosine phosphorylation of DNAM-1, for which the Fyn protein tyrosine kinase is responsible. These results indicate that DNAM-1 is involved in the LFA-1-mediated intracellular signals.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_identifier_34":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2241/102003"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier (Cell Press)","subitem_publisher_language":"en"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10591186","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/S1074-7613(00)80136-3","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(c) 1999 by Cell Press","subitem_rights_language":"en"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1074-7613","subitem_source_identifier_type":"PISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11006671","subitem_source_identifier_type":"NCID"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shibuya, Kazuko","creatorNameLang":"en"},{"creatorName":"渋谷, 和子","creatorNameLang":"ja"},{"creatorName":"シブヤ, カズコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Lanier, Lewis L.","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Phillips, Joseph H.","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ochs, Hans D.","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakayama, Eiichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakauchi, Hiromitsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibuya, Akira","creatorNameLang":"en"},{"creatorName":"渋谷, 彰","creatorNameLang":"ja"},{"creatorName":"シブヤ, アキラ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-19"}],"displaytype":"detail","filename":"Immunity_11-5.pdf","filesize":[{"value":"97.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Immunity_11-5.pdf","objectType":"fulltext","url":"https://tsukuba.repo.nii.ac.jp/record/17546/files/Immunity_11-5.pdf"},"version_id":"5e1bfc55-2019-495b-aec5-bd85247a3a84"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-19"}],"displaytype":"detail","filename":"Immunity_11-5Figs.pdf","filesize":[{"value":"141.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Immunity_11-5Figs.pdf","objectType":"fulltext","url":"https://tsukuba.repo.nii.ac.jp/record/17546/files/Immunity_11-5Figs.pdf"},"version_id":"aca00bec-e9fb-4fb8-b563-dc37acb25059"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Physical and Functional Association of LFA-1 with DNAM-1 Adhesion Molecule","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Physical and Functional Association of LFA-1 with DNAM-1 Adhesion Molecule","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["604","987","543"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-03-25"},"publish_date":"2009-03-25","publish_status":"0","recid":"17546","relation_version_is_last":true,"title":["Physical and Functional Association of LFA-1 with DNAM-1 Adhesion Molecule"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-07-14T04:22:28.109322+00:00"}