@article{oai:tsukuba.repo.nii.ac.jp:00017546,
 author = {Shibuya, Kazuko and 渋谷, 和子 and Lanier, Lewis L. and Phillips, Joseph H. and Ochs, Hans D. and Shimizu, Kenji and Nakayama, Eiichi and Nakauchi, Hiromitsu and Shibuya, Akira and 渋谷, 彰},
 issue = {5},
 journal = {Immunity},
 month = {Nov},
 note = {Whereas ligation of the DNAM-1 adhesion molecule triggers cytotoxicity mediated by normal NK and T cells, this function was defective in NK cell clones from leukocyte adhesion deficiency syndrome. However, genetic reconstitution of cell surface expression of LFA-1 restored the ability of DNAM-1 to initiate anti-DNAM-1 mAb-induced cytotoxicity, indicating a functional relationship between DNAM-1 and LFA-1. Further studies demonstrated that LFA-1 physically associates with DNAM-1 in NK cells and anti-CD3 mAb stimulated T cells, for which serine phosphorylation of DNAM-1 plays a critical role. In addition, crosslinking of LFA-1 induces tyrosine phosphorylation of DNAM-1, for which the Fyn protein tyrosine kinase is responsible. These results indicate that DNAM-1 is involved in the LFA-1-mediated intracellular signals.},
 pages = {615--623},
 title = {Physical and Functional Association of LFA-1 with DNAM-1 Adhesion Molecule},
 volume = {11},
 year = {1999},
 yomi = {シブヤ, カズコ and シブヤ, アキラ}
}