WEKO3
アイテム
{"_buckets": {"deposit": "9c962d64-fc03-4932-bcdd-e575f8625c3c"}, "_deposit": {"created_by": 221, "id": "8967", "owners": [221], "pid": {"revision_id": 0, "type": "depid", "value": "8967"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00008967", "sets": []}, "author_link": ["36454"], "item_12_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1989", "bibliographicIssueDateType": "Issued"}}]}, "item_12_date_granted_46": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "1989-03-25"}]}, "item_12_degree_grantor_44": {"attribute_name": "学位授与大学", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "筑波大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "University of Tsukuba"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "12102", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_12_degree_name_43": {"attribute_name": "取得学位", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}, {"subitem_degreename": "Doctor of Philosophy in Medical Sciences", "subitem_degreename_language": "en"}]}, "item_12_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Using the in vitro quantitative receptor autoradiographical technique, changes in the binding parameters of [propionyl-3H] propionylated CCK-8 ([3H]pCCK-8) binding sites in the rat forebrain were investigated following acute and chronic administration of methamphetamine (MAP). The (Kd)app values of [3H]pCCK-8 binding sites in the frontal medial cortex and anterior cingulate cortex were significantly reduced after a single injection of 4mg/kg MAP. On the other hand, chronic treatment (14 days) with MAP at this dose significantly decreased the Bmax value of [3H]pCCK-8 binding sites in the anterior cingulate cortex accompanied by supersensitivity of locomotor effects to MAP. These findings suggest that dopamine (DA) neurons in these two regions are functionally related to intrinsicCCK-containing cortical neurons, and that CCK subsensitivity, perhaps due to an alteration in DA transmission, is involves in MAP sensitization. These findings may be relevant to the DA hypothesis of schizophrenia.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_12_description_45": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_description": "1988", "subitem_description_type": "Other"}]}, "item_12_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Joint author: T. Moroji", "subitem_description_language": "en", "subitem_description_type": "Other"}, {"subitem_description": "Offprint. Originally published in: Journal of neural transmission, 77, pp. 181-195, 1989", "subitem_description_language": "en", "subitem_description_type": "Other"}, {"subitem_description": "Includes supplementary treatises", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_12_dissertation_number_47": {"attribute_name": "報告番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "乙第518号"}]}, "item_12_relation_37": {"attribute_name": "関係URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_language": "ja", "subitem_relation_name_text": "全文はOPACにあり"}], "subitem_relation_type": "hasFormat", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.tulips.tsukuba.ac.jp/opac/volume/607339", "subitem_relation_type_select": "URI"}}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "鈴木, 利人", "creatorNameLang": "ja"}, {"creatorName": "Suzuki, Toshihito", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "36454", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2013-12-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "B0518.pdf", "filesize": [{"value": "225.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 225500.0, "url": {"objectType": "abstract", "url": "https://tsukuba.repo.nii.ac.jp/record/8967/files/B0518.pdf"}, "version_id": "bf78a38d-a290-4643-910c-8a55cc61a561"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Cholecystokinin binding sites in the rat forebrain : effects of acute and chronic methamphetamine administration", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Cholecystokinin binding sites in the rat forebrain : effects of acute and chronic methamphetamine administration", "subitem_title_language": "en"}]}, "item_type_id": "12", "owner": "221", "path": ["239"], "permalink_uri": "http://hdl.handle.net/2241/6125", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-07-25"}, "publish_date": "2007-07-25", "publish_status": "0", "recid": "8967", "relation": {}, "relation_version_is_last": true, "title": ["Cholecystokinin binding sites in the rat forebrain : effects of acute and chronic methamphetamine administration"], "weko_shared_id": -1}
Cholecystokinin binding sites in the rat forebrain : effects of acute and chronic methamphetamine administration
http://hdl.handle.net/2241/6125
http://hdl.handle.net/2241/6125fee34a62-86de-4ca6-a431-fd46b7f78c5b
名前 / ファイル | ライセンス | アクション |
---|---|---|
B0518.pdf (225.5 kB)
|
|
Item type | Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2007-07-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Cholecystokinin binding sites in the rat forebrain : effects of acute and chronic methamphetamine administration | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
鈴木, 利人
× 鈴木, 利人 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Using the in vitro quantitative receptor autoradiographical technique, changes in the binding parameters of [propionyl-3H] propionylated CCK-8 ([3H]pCCK-8) binding sites in the rat forebrain were investigated following acute and chronic administration of methamphetamine (MAP). The (Kd)app values of [3H]pCCK-8 binding sites in the frontal medial cortex and anterior cingulate cortex were significantly reduced after a single injection of 4mg/kg MAP. On the other hand, chronic treatment (14 days) with MAP at this dose significantly decreased the Bmax value of [3H]pCCK-8 binding sites in the anterior cingulate cortex accompanied by supersensitivity of locomotor effects to MAP. These findings suggest that dopamine (DA) neurons in these two regions are functionally related to intrinsicCCK-containing cortical neurons, and that CCK subsensitivity, perhaps due to an alteration in DA transmission, is involves in MAP sensitization. These findings may be relevant to the DA hypothesis of schizophrenia. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Joint author: T. Moroji | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Offprint. Originally published in: Journal of neural transmission, 77, pp. 181-195, 1989 | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Includes supplementary treatises | |||||
言語 | en | |||||
書誌情報 |
発行日 1989 |
|||||
関係URI | ||||||
関連タイプ | hasFormat | |||||
識別子タイプ | URI | |||||
関連識別子 | https://www.tulips.tsukuba.ac.jp/opac/volume/607339 | |||||
言語 | ja | |||||
関連名称 | 全文はOPACにあり | |||||
取得学位 | ||||||
学位名 | 博士(医学) | |||||
取得学位 | ||||||
学位名 | Doctor of Philosophy in Medical Sciences | |||||
学位授与大学 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 12102 | |||||
言語 | ja | |||||
学位授与機関名 | 筑波大学 | |||||
言語 | en | |||||
学位授与機関名 | University of Tsukuba | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 1988 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 1989-03-25 | |||||
報告番号 | ||||||
学位授与番号 | 乙第518号 |