{"created":"2021-03-01T06:44:28.201084+00:00","id":8967,"links":{},"metadata":{"_buckets":{"deposit":"9c962d64-fc03-4932-bcdd-e575f8625c3c"},"_deposit":{"created_by":221,"id":"8967","owners":[221],"pid":{"revision_id":0,"type":"depid","value":"8967"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00008967","sets":["3:233:239"]},"author_link":["36454"],"item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989","bibliographicIssueDateType":"Issued"}}]},"item_12_date_granted_46":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1989-03-25"}]},"item_12_degree_grantor_44":{"attribute_name":"学位授与大学","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"筑波大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"University of Tsukuba"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"12102","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_12_degree_name_43":{"attribute_name":"取得学位","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"},{"subitem_degreename":"Doctor of Philosophy in Medical Sciences"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Using the in vitro quantitative receptor autoradiographical technique, changes in the binding parameters of [propionyl-3H] propionylated CCK-8 ([3H]pCCK-8) binding sites in the rat forebrain were investigated following acute and chronic administration of methamphetamine (MAP). The (Kd)app values of [3H]pCCK-8 binding sites in the frontal medial cortex and anterior cingulate cortex were significantly reduced after a single injection of 4mg/kg MAP. On the other hand, chronic treatment (14 days) with MAP at this dose significantly decreased the Bmax value of [3H]pCCK-8 binding sites in the anterior cingulate cortex accompanied by supersensitivity of locomotor effects to MAP. These findings suggest that dopamine (DA) neurons in these two regions are functionally related to intrinsicCCK-containing cortical neurons, and that CCK subsensitivity, perhaps due to an alteration in DA transmission, is involves in MAP sensitization. These findings may be relevant to the DA hypothesis of schizophrenia.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_12_description_45":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"1988","subitem_description_type":"Other"}]},"item_12_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Joint author: T. Moroji","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Offprint. Originally published in: Journal of neural transmission, 77, pp. 181-195, 1989","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Includes supplementary treatises","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_12_dissertation_number_47":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第518号"}]},"item_12_relation_37":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"全文はOPACにあり"}],"subitem_relation_type":"hasFormat","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.tulips.tsukuba.ac.jp/opac/volume/607339","subitem_relation_type_select":"URI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 利人","creatorNameLang":"ja"},{"creatorName":"Suzuki, Toshihito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"36454","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-18"}],"displaytype":"detail","filename":"B0518.pdf","filesize":[{"value":"225.5 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tsukuba.repo.nii.ac.jp/record/8967/files/B0518.pdf"},"version_id":"bf78a38d-a290-4643-910c-8a55cc61a561"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Cholecystokinin binding sites in the rat forebrain : effects of acute and chronic methamphetamine administration","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cholecystokinin binding sites in the rat forebrain : effects of acute and chronic methamphetamine administration","subitem_title_language":"en"}]},"item_type_id":"12","owner":"221","path":["239"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-07-25"},"publish_date":"2007-07-25","publish_status":"0","recid":"8967","relation_version_is_last":true,"title":["Cholecystokinin binding sites in the rat forebrain : effects of acute and chronic methamphetamine administration"],"weko_creator_id":"221","weko_shared_id":-1},"updated":"2024-02-08T00:05:22.020282+00:00"}