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Voxel-based correlation of 18F-THK5351 accumulation and gray matter volume in the brain of cognitively normal older adults
http://hdl.handle.net/2241/00159824
http://hdl.handle.net/2241/001598243563ebab-3584-44b5-a669-078f2ea6ca5d
名前 / ファイル | ライセンス | アクション |
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EJNMMI-R_9-81 (1.3 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2020-03-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Voxel-based correlation of 18F-THK5351 accumulation and gray matter volume in the brain of cognitively normal older adults | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
太田, 深秀
× 太田, 深秀× Shigemoto, Yoko× Sone, Daichi× Maikusa, Norihide× Ogawa, Masayo× Okita, Kyoji× Takano, Harumasa× Kato, Koichi× Kimura, Yukio× Morimoto, Emiko× Suzuki, Fumio× Fujii, Hiroyuki× Sato, Noriko× Matsuda, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Backgrounds Although neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) volume in cognitively normal older adults. Here, we investigated the correlations between 18F-THK5351 accumulation and GM volume at the voxel level. Material and methods We recruited 47 amyloid-negative, cognitively normal, older adults (65.0 ± 7.9 years, 26 women), who underwent structural magnetic resonance imaging, 11C-Pittsburgh compound-B and 18F-THK5351 PET scans, and neuropsychological assessment. The magnetic resonance and 18F-THK5351 PET images were spatially normalized using Statistical Parametric Mapping 12. Voxel-wise correlations between 18F-THK5351 accumulation and GM volume were evaluated using the Biological Parametric Mapping toolbox. Results A significant negative correlation (p < 0.001) between 18F-THK5351 accumulation and GM volume was detected in the bilateral medial temporal lobes. Conclusions Voxel-wise correlation analysis revealed a significant negative correlation between 18F-THK5351 accumulation and GM volume in the medial temporal lobe in individuals without amyloid-β deposits. These results may contribute to a better understanding of the pathophysiology of primary age-related tauopathy in human aging. |
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書誌情報 |
en : EJNMMI Research 巻 9, p. 81, 発行日 2019-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2191-219X | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 31444646 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s13550-019-0552-3 | |||||
権利 | ||||||
権利情報 | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Springer |