@article{oai:tsukuba.repo.nii.ac.jp:00054402,
 author = {太田, 深秀 and OTA, Miho and Shigemoto, Yoko and Sone, Daichi and Maikusa, Norihide and Ogawa, Masayo and Okita, Kyoji and Takano, Harumasa and Kato, Koichi and Kimura, Yukio and Morimoto, Emiko and Suzuki, Fumio and Fujii, Hiroyuki and Sato, Noriko and Matsuda, Hiroshi},
 journal = {EJNMMI Research},
 month = {Aug},
 note = {Backgrounds
Although neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) volume in cognitively normal older adults. Here, we investigated the correlations between 18F-THK5351 accumulation and GM volume at the voxel level.

Material and methods
We recruited 47 amyloid-negative, cognitively normal, older adults (65.0 ± 7.9 years, 26 women), who underwent structural magnetic resonance imaging, 11C-Pittsburgh compound-B and 18F-THK5351 PET scans, and neuropsychological assessment. The magnetic resonance and 18F-THK5351 PET images were spatially normalized using Statistical Parametric Mapping 12. Voxel-wise correlations between 18F-THK5351 accumulation and GM volume were evaluated using the Biological Parametric Mapping toolbox.

Results
A significant negative correlation (p < 0.001) between 18F-THK5351 accumulation and GM volume was detected in the bilateral medial temporal lobes.

Conclusions
Voxel-wise correlation analysis revealed a significant negative correlation between 18F-THK5351 accumulation and GM volume in the medial temporal lobe in individuals without amyloid-β deposits. These results may contribute to a better understanding of the pathophysiology of primary age-related tauopathy in human aging.},
 title = {Voxel-based correlation of 18F-THK5351 accumulation and gray matter volume in the brain of cognitively normal older adults},
 volume = {9},
 year = {2019},
 yomi = {オオタ, ミホ}
}