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Aplysiasecosterol A: A 9,11-Secosteroid with an Unprecedented Tricyclic γ-Diketone Structure from the Sea Hare Aplysia kurodai
http://hdl.handle.net/2241/00125563
http://hdl.handle.net/2241/00125563e3c23e34-c695-484d-8a63-9767e9c0d873
名前 / ファイル | ライセンス | アクション |
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Item type | Journal Article(1) | |||||
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公開日 | 2015-07-31 | |||||
タイトル | ||||||
タイトル | Aplysiasecosterol A: A 9,11-Secosteroid with an Unprecedented Tricyclic γ-Diketone Structure from the Sea Hare Aplysia kurodai | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
Kawamura, Atsushi
× Kawamura, Atsushi× 北, 将樹× 木越, 英夫 |
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内容記述 | ||||||
内容記述 | A new 9,11-secosteroid having an unprecedented tricyclic γ-diketone structure, aplysiasecosterol A (1), was isolated from the sea hare Aplysia kurodai. The structure was determined by one- and two-dimensional NMR spectroscopic analysis, molecular modeling studies, a comparison of experimental and calculated ECD spectra, and a modified Mosher′s method. Aplysiasecosterol A (1) exhibited cytotoxicity against human myelocytic leukemia HL-60 cells. A biosynthetic pathway for 1 from a known cholesterol was proposed and includes twice α-ketol rearrangements and an intramolecular acetalization. | |||||
書誌情報 |
en : Angewandte Chemie International Edition 巻 54, 号 24, p. 7073-7076, 発行日 2015-06 |
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ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1433-7851 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | https://doi.org/10.1002/anie.201501749 | |||||
PMID | ||||||
関連識別子 | 25925956 | |||||
権利情報 | ||||||
権利情報 | © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | |||||
権利情報 | ||||||
権利情報 | This is the peer reviewed version of the following article: Angew. Chem. Int. Ed. 2015, 54, 7073 –7076, which has been published in final form at 10.1002/anie.201501749. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
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出版者 | Wiley-VCH |