@article{oai:tsukuba.repo.nii.ac.jp:00034582, author = {北, 将樹 and 木越, 英夫 and Kawamura, Atsushi and Kita, Masaki and 木越, 英夫}, issue = {24}, journal = {Angewandte Chemie International Edition}, month = {Jun}, note = {A new 9,11-secosteroid having an unprecedented tricyclic γ-diketone structure, aplysiasecosterol A (1), was isolated from the sea hare Aplysia kurodai. The structure was determined by one- and two-dimensional NMR spectroscopic analysis, molecular modeling studies, a comparison of experimental and calculated ECD spectra, and a modified Mosher′s method. Aplysiasecosterol A (1) exhibited cytotoxicity against human myelocytic leukemia HL-60 cells. A biosynthetic pathway for 1 from a known cholesterol was proposed and includes twice α-ketol rearrangements and an intramolecular acetalization.}, pages = {7073--7076}, title = {Aplysiasecosterol A: A 9,11-Secosteroid with an Unprecedented Tricyclic γ-Diketone Structure from the Sea Hare Aplysia kurodai}, volume = {54}, year = {2015}, yomi = {キゴシ, ヒデオ} }