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(−)-Epigallocatechin gallate suppresses adipocyte differentiation through the MEK/ERK and PI3K/Akt pathways
http://hdl.handle.net/2241/119305
http://hdl.handle.net/2241/119305fddd0ebe-b3e9-4526-ad93-3600501dbb0d
名前 / ファイル | ライセンス | アクション |
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CBI_36-2.pdf (397.2 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2013-05-31 | |||||
タイトル | ||||||
タイトル | (−)-Epigallocatechin gallate suppresses adipocyte differentiation through the MEK/ERK and PI3K/Akt pathways | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kim, Hyojung
× Kim, Hyojung× Sakamoto, Kazuichi |
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著者別名 |
坂本, 和一
× 坂本, 和一 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | EGCG [(−)-epigallocatechin gallate], tea catechin, is one of the compounds that has been reported to act against obesity and diabetes. To determine the effect of EGCG on adipocyte differentiation, we treated 3T3-L1 preadipocytes with different catechins. Oil Red O staining showed significantly reduced intracellular lipid accumulation, especially with EGCG. Cell cycle analysis showed that EGCG inhibited cell proliferation by disturbing the cell cycle during the clonal expansion of 3T3-L1. RT-PCR (real-time PCR) demonstrated that EGCG noticeably reduced mRNA expression of PPARγ (peroxisome proliferator-activated receptor γ), C/EBPα (CCAAT/enhancer-binding protein α) and FoxO1 (forkhead box class O1). EGCG also caused a significant decrease in the transcription of FoxO1 – the forkhead transcription factor class O1 involved in adipocyte differentiation – via the PI3K (phosphoinositide 3-kinase)/Akt and MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase] pathways. These results suggest that EGCG suppresses the clonal expansion of adipocytes by inactivating FoxO1 via insulin signalling and stress-dependent MAPK pathways. | |||||
書誌情報 |
Cell biology international 巻 36, 号 2, p. 147-153, 発行日 2012-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1065-6995 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10882014 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 21902673 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1042/CBI20110047 | |||||
権利 | ||||||
権利情報 | © The Author(s) Journal compilation © 2012 Portland Press Limited The Version of Record (VoR) is available at http://www.cellbiolint.org | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Portland Press Limited | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/119305 | |||||
識別子タイプ | HDL |