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Effect of plasma lipids, hypertension and APOE genotype on cognitive decline
http://hdl.handle.net/2241/117842
http://hdl.handle.net/2241/1178426fbcaefe-3d79-4b20-9d95-f0746748b845
名前 / ファイル | ライセンス | アクション |
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TL_53-28.pdf (168.1 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2012-11-12 | |||||
タイトル | ||||||
タイトル | Effect of plasma lipids, hypertension and APOE genotype on cognitive decline | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yasuno, Fumihiko
× Yasuno, Fumihiko× Tanimukai, Satoshi× Sasaki, Megumi× Ikejima, Chiaki× Yamashita, Fumio× Kodama, Chiine× Hidaka, Shin× Mizukami, Katsuyoshi× Asada, Takashi |
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著者別名 |
安野, 史彦
× 安野, 史彦× 池嶋, 千秋× 水上, 勝義× 朝田, 隆 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the combined effect of plasma lipids/hypertension and apolipoprotein E (APOE) genotype on cognitive function in elderly individuals. Plasma concentrations of high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC), APOE, and history of hypertension were evaluated in 622 community-dwelling individuals aged 65 years and older. We investigated the associations between plasma lipids/hypertension and cognitive function in apolipoprotein E4 allele (APOE4) carrier (E4+) and APOE4 noncarrier (E4–) groups using 3-year longitudinal data. At baseline and 3 years later, cognitive scores were correlated with plasma APOE levels in both E4– and E4+, and HDL level in E4–. The combination of hypertension and E4+, but not E4–, was associated with a significant deterioration in cognitive function during the 3-year follow-up. Our findings suggest that an interaction between APOE and HDL is facilitated by APOE4, and is possibly linked with a protective effect on cognitive decline in later life. The findings also indicate a synergistic effect of an APOE4 allele and hypertension on the acceleration of cognitive decline. | |||||
書誌情報 |
Neurobiology of aging 巻 33, 号 11, p. 2633-2640, 発行日 2012-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0197-4580 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10618297 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 22285757 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.neurobiolaging.2011.12.028 | |||||
権利 | ||||||
権利情報 | © 2012 Elsevier Inc. NOTICE: this is the author’s version of a work that was accepted for publication in Neurobiology of aging. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, Volume 33, Issue 11, 2012 DOI:10.1016/j.neurobiolaging.2011.12.028 |
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著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier Inc. | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/117842 | |||||
識別子タイプ | HDL |