@article{oai:tsukuba.repo.nii.ac.jp:00027887,
 author = {安野, 史彦 and 池嶋, 千秋 and 水上, 勝義 and 朝田, 隆 and Yasuno, Fumihiko and Tanimukai, Satoshi and Sasaki, Megumi and Ikejima, Chiaki and Yamashita, Fumio and Kodama, Chiine and Hidaka, Shin and Mizukami, Katsuyoshi and Asada, Takashi},
 issue = {11},
 journal = {Neurobiology of aging},
 month = {Nov},
 note = {We examined the combined effect of plasma lipids/hypertension and apolipoprotein E (APOE) genotype on cognitive function in elderly individuals. Plasma concentrations of high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC), APOE, and history of hypertension were evaluated in 622 community-dwelling individuals aged 65 years and older. We investigated the associations between plasma lipids/hypertension and cognitive function in apolipoprotein E4 allele (APOE4) carrier (E4+) and APOE4 noncarrier (E4–) groups using 3-year longitudinal data. At baseline and 3 years later, cognitive scores were correlated with plasma APOE levels in both E4– and E4+, and HDL level in E4–. The combination of hypertension and E4+, but not E4–, was associated with a significant deterioration in cognitive function during the 3-year follow-up. Our findings suggest that an interaction between APOE and HDL is facilitated by APOE4, and is possibly linked with a protective effect on cognitive decline in later life. The findings also indicate a synergistic effect of an APOE4 allele and hypertension on the acceleration of cognitive decline.},
 pages = {2633--2640},
 title = {Effect of plasma lipids, hypertension and APOE genotype on cognitive decline},
 volume = {33},
 year = {2012}
}