| Item type |
Journal Article(1) |
| 公開日 |
2021-11-08 |
| タイトル |
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|
タイトル |
The effect of roller head pump on platelet deterioration during the simulated extracorporeal circulation |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
Furugaki, Tatsuya
Shigeta, Osamu
Kozuma, Yukinori
Tsukada, Toru
Nakajima, Tomomi
SAKAMOTO, Hiroaki
MATHIS, Bryan James
HIRAMATSU, Yuji
SUZUKI, Yasuyuki
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| 著者情報 |
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表示名 |
医学医療系; 坂本, 裕昭; サカモト, ヒロアキ; SAKAMOTO, Hiroaki |
|
URL |
http://trios.tsukuba.ac.jp/researcher/0000003064 |
| 著者情報 |
|
|
表示名 |
医学医療系; マティス, ブライアン ジェームズ; マティス, ブライアン ジェームズ; MATHIS, Bryan James |
|
URL |
http://trios.tsukuba.ac.jp/researcher/0000003913 |
| 著者情報 |
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表示名 |
筑波大学; 平松, 祐司; ヒラマツ, ユウジ; HIRAMATSU, Yuji |
|
URL |
http://trios.tsukuba.ac.jp/researcher/0000001916 |
| 著者情報 |
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表示名 |
医学医療系; 鈴木, 保之; スズキ, ヤスユキ; SUZUKI, Yasuyuki |
|
URL |
http://trios.tsukuba.ac.jp/researcher/0000004272 |
| 抄録 |
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内容記述 |
Roller pumping results in hemolysis and adverse effects on coagulation, but there are few reports on the influence of roller heads on platelets. Here, we evaluate the interaction between roller pumping and platelet function using a simulated extracorporeal circuit incorporating a vinyl chloride tube and roller head pump with 30 min recirculation. Platelet aggregation, platelet count, microparticle, P-selectin, Phosphatidylserine (PS) exposure and Ricinus Communis Agglutinin 1 (RCA-1) were measured before, 5, 10, 20, and 30 min after the recirculation using 100 ml of fresh human blood that had obtained from healthy volunteers (n = 9). Platelet aggregation and platelet count gradually decreased but microparticles significantly increased after the recirculation (P < 0.05). P-selectin, PS exposure and RCA-1 were measured using flow cytometry. There were no significant differences in the P-selectin and PS exposure expression during recirculation. RCA-1, a platelet apoptosis markers, significantly increased 30 min after recirculation (P < 0.05). We thus conclude that roller pumping induced platelet apoptosis and caused decreases in platelet count and aggregation after the recirculation. |
| 書誌情報 |
en : Journal of Artificial Organs
巻 24,
号 1,
p. 22-26,
発行日 2021-03
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| PISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1434-7229 |
| NCID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11283795 |
| アクセス権 |
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アクセス権 |
open access |
| 権利情報 |
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|
権利情報 |
© The Japanese Society for Artificial Organs 2020. This is a post-peer-review, pre-copyedit version of an article published in Journal of Artificial Organs. The final authenticated version is available online at https://doi.org/10.1007/s10047-020-01192-x. |
| 出版者 |
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出版者 |
Springer |
| 出版タイプ |
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出版タイプ |
AM |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
関連識別子 |
https://doi.org/10.1007/s10047-020-01192-x |
| PMID |
|
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関連識別子 |
32620985 |
JAO-24_1_22.pdf (380 KB)
