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Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
http://hdl.handle.net/2241/102314
http://hdl.handle.net/2241/10231419fb9c90-d0a9-4c62-bcf0-86308c946bc2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JCI_89-2.pdf (1.5 MB)
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| Item type | Journal Article(1) | |||||
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| 公開日 | 2009-04-28 | |||||
| タイトル | ||||||
| タイトル | Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
山田, 信博
× 山田, 信博× Inoue, Ikuo× Kawamura, Masako× Harada, Kenji× Watanabe, Yoshiro× Shimano, Hitoshi× Gotoda, Takanari× Shimada, Masako× Kohzaki, Kohichi× Tsukada, Toyohiro× Shiomi, Masashi× Watanabe, Yoshio× Yazaki, Yoshio |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Apo E plays an important role in plasma lipoprotein metabolism through its high affinity binding to cell surface LDL receptor. In the present study, we studied the effects of apo E on the atherogenic process in Watanabe heritable hyperlipidemic rabbits which are deficient in LDL receptor and an animal model for familial hypercholesterolemia. We isolated apo E from plasma of 1% cholesterol-fed rabbits and administered 10 mg of purified apo E intravenously into five Watanabe heritable hyperlipidemic rabbits three times a week from their age of 2.5 months to 11 months for 8.5 months. After sustained administration to apo E, we found a significant reduction in the accumulation of cholesterol ester in aortae (1.55 +/- 0.07 mg/g tissue) as compared to control rabbits (4.32 +/- 0.61 mg/g tissue). Supporting this, the percentage of the surface area of the aorta with macroscopic plaque was remarkably decreased in apo E-treated animals (18.8 +/- 5.1% vs. 38.8 +/- 8.0% in control). Thus, apo E definitely prevented the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : The journal of clinical investigation 巻 89, 号 2, p. 706-711, 発行日 1992-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0021-9738 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00695520 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1172/JCI115639 | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 1737858 | |||||
| 権利情報 | ||||||
| 言語 | en | |||||
| 権利情報 | © The American Society for Clinical Investigation | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | The American Society for Clinical Investigation | |||||
| 言語 | en | |||||
