@article{oai:tsukuba.repo.nii.ac.jp:00017626, author = {山田, 信博 and YAMADA, Nobuhiro and Inoue, Ikuo and Kawamura, Masako and Harada, Kenji and Watanabe, Yoshiro and Shimano, Hitoshi and Gotoda, Takanari and Shimada, Masako and Kohzaki, Kohichi and Tsukada, Toyohiro and Shiomi, Masashi and Watanabe, Yoshio and Yazaki, Yoshio}, issue = {2}, journal = {The journal of clinical investigation}, month = {Feb}, note = {Apo E plays an important role in plasma lipoprotein metabolism through its high affinity binding to cell surface LDL receptor. In the present study, we studied the effects of apo E on the atherogenic process in Watanabe heritable hyperlipidemic rabbits which are deficient in LDL receptor and an animal model for familial hypercholesterolemia. We isolated apo E from plasma of 1% cholesterol-fed rabbits and administered 10 mg of purified apo E intravenously into five Watanabe heritable hyperlipidemic rabbits three times a week from their age of 2.5 months to 11 months for 8.5 months. After sustained administration to apo E, we found a significant reduction in the accumulation of cholesterol ester in aortae (1.55 +/- 0.07 mg/g tissue) as compared to control rabbits (4.32 +/- 0.61 mg/g tissue). Supporting this, the percentage of the surface area of the aorta with macroscopic plaque was remarkably decreased in apo E-treated animals (18.8 +/- 5.1% vs. 38.8 +/- 8.0% in control). Thus, apo E definitely prevented the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.}, pages = {706--711}, title = {Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.}, volume = {89}, year = {1992}, yomi = {ヤマダ, ノブヒロ} }