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Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits
http://hdl.handle.net/2241/102311
http://hdl.handle.net/2241/10231155acb5c4-8c0a-4d78-9ee1-f1cca52ac31b
名前 / ファイル | ライセンス | アクション |
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JCI_80-2.pdf (1.8 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2009-04-27 | |||||
タイトル | ||||||
タイトル | Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits | |||||
言語 | ||||||
言語 | eng | |||||
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資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
著者 |
山田, 信博
× 山田, 信博× Shames, David M.× Havel, Richard J. |
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抄録 | ||||||
内容記述 | The kinetics of apolipoprotein (apo) B-100 in particles containing apo E (B,E particles) or lacking apo E (B particles) were studied in Watanabe heritable hyperlipidemic (WHHL) rabbits deficient in low density lipoprotein (LDL) receptors, and compared with those of normal rabbits after injection of radioiodinated very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL), and LDL. In both groups results of kinetic modeling were consistent with the hypothesis that all apo B enters the plasma in VLDL, mainly as B,E particles, followed by delipidation and partial conversion to IDL and LDL, with concomitant conversion of some B,E particles to B particles. In WHHL rabbits, production of VLDL apo B was reduced by 40%, but LDL production was increased threefold. Defective removal of B,E and B particles in all three lipoprotein classes, coupled with preserved processes of delipidation, can account for the observed increases in the concentration of apo B (threefold in VLDL, fivefold in IDL, and twenty-twofold in LDL) in WHHL rabbits. | |||||
書誌情報 |
en : The journal of clinical investigation 巻 80, 号 2, p. 507-515, 発行日 1987-08 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0021-9738 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695520 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
関連識別子 | https://doi.org/10.1172/JCI113099 | |||||
PMID | ||||||
関連識別子 | 3611356 | |||||
権利情報 | ||||||
権利情報 | © The American Society for Clinical Investigation | |||||
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出版タイプ | VoR | |||||
出版者 | ||||||
出版者 | The American Society for Clinical Investigation |