{"created":"2021-03-01T06:54:52.741472+00:00","id":17623,"links":{},"metadata":{"_buckets":{"deposit":"c2f61110-95de-4766-842e-9beaefb61f56"},"_deposit":{"created_by":188,"id":"17623","owners":[188],"pid":{"revision_id":0,"type":"depid","value":"17623"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00017623","sets":["1722922372414:2780:761","3:1722557955661:5592:675"]},"author_link":["62654","62655"],"item_1644910766877":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"515","bibliographicPageStart":"507","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"The journal of clinical investigation","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The kinetics of apolipoprotein (apo) B-100 in particles containing apo E (B,E particles) or lacking apo E (B particles) were studied in Watanabe heritable hyperlipidemic (WHHL) rabbits deficient in low density lipoprotein (LDL) receptors, and compared with those of normal rabbits after injection of radioiodinated very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL), and LDL. In both groups results of kinetic modeling were consistent with the hypothesis that all apo B enters the plasma in VLDL, mainly as B,E particles, followed by delipidation and partial conversion to IDL and LDL, with concomitant conversion of some B,E particles to B particles. In WHHL rabbits, production of VLDL apo B was reduced by 40%, but LDL production was increased threefold. Defective removal of B,E and B particles in all three lipoprotein classes, coupled with preserved processes of delipidation, can account for the observed increases in the concentration of apo B (threefold in VLDL, fivefold in IDL, and twenty-twofold in LDL) in WHHL rabbits.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The American Society for Clinical Investigation","subitem_publisher_language":"en"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"3611356","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1172/JCI113099","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The American Society for Clinical Investigation","subitem_rights_language":"en"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-9738","subitem_source_identifier_type":"PISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00695520","subitem_source_identifier_type":"NCID"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 信博","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ノブヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"YAMADA, Nobuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"40200729","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/nrid/1000040200729"},{"nameIdentifier":"0000000030","nameIdentifierScheme":"筑波大学研究者総覧","nameIdentifierURI":"http://trios.tsukuba.ac.jp/researcher/0000000030"}]},{"creatorNames":[{"creatorName":"Shames, David M.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"62654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Havel, Richard J.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"62655","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-19"}],"displaytype":"detail","filename":"JCI_80-2.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tsukuba.repo.nii.ac.jp/record/17623/files/JCI_80-2.pdf"},"version_id":"a733de4b-12f2-4078-9bf2-e2e475bf796e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits","subitem_title_language":"en"}]},"item_type_id":"5","owner":"188","path":["761","675"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-04-27"},"publish_date":"2009-04-27","publish_status":"0","recid":"17623","relation_version_is_last":true,"title":["Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits"],"weko_creator_id":"188","weko_shared_id":-1},"updated":"2024-01-25T07:45:27.798003+00:00"}