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Characterization of angiotensin II receptor subtype

http://hdl.handle.net/2241/6169
http://hdl.handle.net/2241/6169
c1ebb07c-3929-4660-ad7f-ad8bfed79453
名前 / ファイル ライセンス アクション
A1160.pdf A1160.pdf (336.9 kB)
Item type アイテムタイプT(1)
公開日 2007-07-25
タイトル
タイトル Characterization of angiotensin II receptor subtype
言語
言語 jpn
資源タイプ
資源タイプ doctoral thesis
著者 大西、淳之

× 大西、淳之

WEKO 36890

en Ohnishi, Junji

ja 大西、淳之

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内容記述 The renin-angiotensin system plays an important role in regulating blood pressure and electrolyte homeostasis (1-3). It operates through formation of the biologically activ octapeptide, angiotensin II (Ang II ) via sequential cleavage of circulating angiotensinogen and angiotensin I by renal renin and angiotensin-converting enzyme, respectively. Recently, numerous evidences have been accumulated suggesting that local renin-angiotensin systems exist in several oragans including the brain, adrenal, kidney, arterial walls, testis, and ovary (4), and research is in progress to outline their function. Ang II is through to generate the variety of effects through interaction with a cell surface specific receptor that subsequently transduces its signal into the appropriate cellular response. The existence of Ang II receptor subtypes has been suggested based on deiffrences in their physiological and biochemical characteristics (5-7). For example, Douglas (6) classified two types of Ang II receptor in rate renal cortex according to differences in affinity for Ang II and Ang III, the nature of receptor regulation and mechanisms of signal transduction. Gunther (7), on the other hand, described two subtypes of Ang II receptor in rat liver on deifferential ・・・
書誌情報
発行日 1993
アクセス権
アクセス権 open access
取得学位
学位名 博士(学術)
取得学位
学位名 Doctor of Philosophy
学位授与大学
学位授与機関名 筑波大学
学位授与機関名 University of Tsukuba
学位授与年度
内容記述 1992
学位授与年月日
学位授与年月日 1993-03-25
報告番号
学位授与番号 甲第1160号
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