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Characterization of angiotensin II receptor subtype
http://hdl.handle.net/2241/6169
http://hdl.handle.net/2241/6169c1ebb07c-3929-4660-ad7f-ad8bfed79453
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
A1160.pdf (336.9 kB)
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| Item type | アイテムタイプT(1) | |||||
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| 公開日 | 2007-07-25 | |||||
| タイトル | ||||||
| タイトル | Characterization of angiotensin II receptor subtype | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ | doctoral thesis | |||||
| 著者 |
大西、淳之
× 大西、淳之 |
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| 抄録 | ||||||
| 内容記述 | The renin-angiotensin system plays an important role in regulating blood pressure and electrolyte homeostasis (1-3). It operates through formation of the biologically activ octapeptide, angiotensin II (Ang II ) via sequential cleavage of circulating angiotensinogen and angiotensin I by renal renin and angiotensin-converting enzyme, respectively. Recently, numerous evidences have been accumulated suggesting that local renin-angiotensin systems exist in several oragans including the brain, adrenal, kidney, arterial walls, testis, and ovary (4), and research is in progress to outline their function. Ang II is through to generate the variety of effects through interaction with a cell surface specific receptor that subsequently transduces its signal into the appropriate cellular response. The existence of Ang II receptor subtypes has been suggested based on deiffrences in their physiological and biochemical characteristics (5-7). For example, Douglas (6) classified two types of Ang II receptor in rate renal cortex according to differences in affinity for Ang II and Ang III, the nature of receptor regulation and mechanisms of signal transduction. Gunther (7), on the other hand, described two subtypes of Ang II receptor in rat liver on deifferential ･･･ | |||||
| 書誌情報 |
発行日 1993 |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 取得学位 | ||||||
| 学位名 | 博士（学術） | |||||
| 取得学位 | ||||||
| 学位名 | Doctor of Philosophy | |||||
| 学位授与大学 | ||||||
| 学位授与機関名 | 筑波大学 | |||||
| 学位授与機関名 | University of Tsukuba | |||||
| 学位授与年度 | ||||||
| 内容記述 | 1992 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 1993-03-25 | |||||
| 報告番号 | ||||||
| 学位授与番号 | 甲第1160号 | |||||
