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弧発性パーキンソン病患者の飲酒様態、パーソナリティおよびL-ドーパ誘発性幻覚に関する研究
http://hdl.handle.net/2241/6117
http://hdl.handle.net/2241/6117d83f4191-2ab9-451a-ae69-5f268b68a7f2
| Item type | Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-07-25 | |||||
| タイトル | ||||||
| タイトル | Studies on drinking behavior, personality and L-dopa induced hallucination of idiopathic Parkinson's disease patients | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 弧発性パーキンソン病患者の飲酒様態、パーソナリティおよびL-ドーパ誘発性幻覚に関する研究 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
藤井, 千枝子
× 藤井, 千枝子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The etiology of idiopathic Parkinson's disease(PD) remains unknown although it has been suggested that PD is a multifactorial deisease caused by environmental and genetic risk factors.A number of studies have characterized life styles, psychological traits and clinical symptoms for idiopathic PD.Especially,the tendency to dislike alcohol,the low score of the novelty seeking(NS)and the high score of the harm avoidance(HA)in Tridimensional Personality Questionnaire(TPQ),and individual difference of the occurrence of L-dopa induced hallucination in PD may involve the genetic backgrounds. This study was carried out to confirm the personality characteristic of Caucasian patients by using Japanese patients,and to elucidate the genetic background with specific reference with polymorphism of the ALDH2 and cholecystokinin(CCK)genes. A total of 116 Japanese outpatients with PD diagnosed by three neurologists from 4 hospitals in Kanto area were analyzed for these studies. Among them 93 patients with PD were analyzed for ALDH2 genotypes and alcohol consumption, and 67 Japanese PD patyients were used for TPQ assessments.All patients(116)were analyzed in order to investigate the role of polymorphism of the CCK gene.Age matched control groups(297 subject for ALDH2 genotyping and alcohol consumption,69 subjects for TPQ,and 95 subjects for the CCK gene polimorphism)were analyzed. PCR-SSCP(polymerase chain reaction-single strand conformational change polymorphism)analysis was used to determine ALDH2 and CCK genotypes.Mean values of alcohol consumption(ethanol g/month/person)and TPQ from patients with PD were estimated by direct interview,and those from controls were obtained by questionnaire.The comparison between PD patients and control subjects were analyzed using a chi-square ... | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Includes supplementary treatises | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Includes bibliographical references | |||||
| 言語 | en | |||||
| 書誌情報 |
発行日 2000 |
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| 取得学位 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士（医学） | |||||
| 取得学位 | ||||||
| 言語 | en | |||||
| 学位名 | Doctor of Philosophy in Medical Sciences | |||||
| 学位授与大学 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 12102 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 筑波大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | University of Tsukuba | |||||
| 学位授与年度 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 1999 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2000-03-24 | |||||
| 報告番号 | ||||||
| 学位授与番号 | 甲第2426号 | |||||
