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Molecular and biochemical studies of the Bacillus subtilis FtsY protein, a homologue of the α subunit of mammalian signal recognition particle
http://hdl.handle.net/2241/6823
http://hdl.handle.net/2241/6823e2f66f29-cd35-4aff-a741-b2d3600cef10
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Item type | Thesis or Dissertation(1) | |||||
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公開日 | 2007-07-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Molecular and biochemical studies of the Bacillus subtilis FtsY protein, a homologue of the α subunit of mammalian signal recognition particle | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
掛下, 大視
× 掛下, 大視 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In mammalian cellls, the signal recognition particle(SRP) and the SRP receptor play a central role in targeting presecretory proteins to the membrane of the endoplasmic reticulum(ER). SRP is a ribonucleo-protein complex composed of one RNA(SRP 7S RNA) molecule and six proteins of 9, 14, 19, 54, 68, and 72 kDa. SRP interacts with the signal sequence of nascent polypeptide emerging from ribosomes and the complex formed is targeted and bound to a hetero-dimeric receptor consisting of SRα and SRβ on the ER. In contrast, it has been considered that the chaperones and Sec proteins play a pivotal role in targeting and translocation of secretory proteins in Escherichia coli. However, recently, the molecular homologues to the components of mammalian SRP have been identified in prokaryotes. In E. coli, 4.5S RNA and E. coli Ffh protein have been identified as homologues to the SRP 7S RNA and SRP54 of mammalian SRP, respectively. Furthermore, FtsY exhibits a homology with SRα. In Bacillus subtilis, small cytoplasmic RNA(scRNA) and B. subtilis Ffh protein have been also identified as homologues to the SRP 7S RNA and SRP54, respectively. Depletion of either the SRP RNA or SRP54 homologues ・・・ | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Includes bibliographical references | |||||
言語 | en | |||||
書誌情報 |
発行日 2001 |
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取得学位 | ||||||
学位名 | 博士(理学) | |||||
取得学位 | ||||||
学位名 | Doctor of Philosophy in Science | |||||
学位授与大学 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 12102 | |||||
言語 | ja | |||||
学位授与機関名 | 筑波大学 | |||||
言語 | en | |||||
学位授与機関名 | University of Tsukuba | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2000 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2001-03-23 | |||||
報告番号 | ||||||
学位授与番号 | 乙第1714号 |