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  1. 医学医療系 (Faculty of Medicine)
  2. 丸尾 和司 (Maruo Kazushi)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. J~
  4. JAMA Network Open

Augmentation of Positive Valence System–Focused Cognitive Behavioral Therapy by Inaudible High-Frequency Sounds for Anhedonia : A Trial Protocol for a Pilot Study

http://hdl.handle.net/2241/00161471
efc9ac52-36f4-47ad-90a8-442af4551cfb
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名前 / ファイル ライセンス Actions
JAMANO_2-11.pdf JAMANO_2-11 (986.3 kB)
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item type Journal Article(1)
公開日 2020-09-28
タイトル
言語 en
タイトル Augmentation of Positive Valence System–Focused Cognitive Behavioral Therapy by Inaudible High-Frequency Sounds for Anhedonia : A Trial Protocol for a Pilot Study
言語
言語 eng
資源タイプ
タイプ journal article
著者 丸尾, 和司

× 丸尾, 和司

WEKO 204869
e-Rad 10777999
筑波大学研究者総覧 0000004041

丸尾, 和司

ja-Kana マルオ, カズシ

en MARUO, Kazushi

Search repository
Ito, Masaya

× Ito, Masaya

WEKO 222997

en Ito, Masaya

Search repository
Miyamae, Mitsuhiro

× Miyamae, Mitsuhiro

WEKO 222998

en Miyamae, Mitsuhiro

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Yokoyama, Chika

× Yokoyama, Chika

WEKO 222999

en Yokoyama, Chika

Search repository
Yamashita, Yuichi

× Yamashita, Yuichi

WEKO 223000

en Yamashita, Yuichi

Search repository
Ueno, Osamu

× Ueno, Osamu

WEKO 223001

en Ueno, Osamu

Search repository
Komazawa, Asami

× Komazawa, Asami

WEKO 223002

en Komazawa, Asami

Search repository
Niwa, Madoka

× Niwa, Madoka

WEKO 223003

en Niwa, Madoka

Search repository
Honda, Manabu

× Honda, Manabu

WEKO 223004

en Honda, Manabu

Search repository
Horikoshi, Masaru

× Horikoshi, Masaru

WEKO 223005

en Horikoshi, Masaru

Search repository
抄録
内容記述 Importance
Recent conceptualizations in Research Domain Criteria have indicated that anhedonia, 1 of 2 core symptoms of depression, which can be treatment resistant, is associated with deficits in the positive valence system, and inaudible high-frequency sound therapy has been shown to enhance reward-related brain circuitry. Hence, cognitive behavioral therapy focusing on the positive valence system enhanced with sound therapy could have a synergistic effect on anhedonia.

Objective
To test the augmentation effect of inaudible high-frequency sounds on the efficacy of positive valence system–focused cognitive behavioral therapy to treat anhedonia.

Design, Setting, and Participants
In this individual-level allocation, exploratory, single-center randomized superiority pilot trial, patients, therapists, and evaluators will be masked to intervention or placebo assignment. The trial will take place at a national psychiatric referral hospital in Tokyo, Japan, among 44 adult patients with clinically significant anhedonia and moderate to severe depression. Outcomes will be analyzed following the intent-to-treat principle using a repeated-measures mixed model.

Intervention
The intervention group will participate in 8 weekly sessions of positive valence system–focused cognitive behavioral therapy with in-session exposure to an inaudible high-frequency sound; the comparison group will undergo cognitive behavioral therapy with in-session exposure to a placebo sound.

Main Outcomes and Measures
The primary outcome is anhedonia assessed using the self-reported Snaith-Hamilton Pleasure Scale. The secondary outcome is anhedonia assessed using the clinician-administered version of the Snaith-Hamilton Pleasure Scale.

Discussion
Recruitment for this study began in May 2018, and the projected date of final allocation is January 2020. A total of 21 eligible patients were registered for participation as of May 30, 2019. To date, treatments for depression do not guarantee clinically successful outcomes. This pilot trial will provide preliminary evidence of the augmentation effect of high-frequency inaudible sounds on cognitive behavioral therapy for anhedonia. Overall, exposure to an inaudible high-frequency sounds does not require attentional or cognitive effort from either patients or therapists; therefore, results from a future confirmative trial could indicate that cognitive behavioral therapy can be augmented in an effortless manner.
書誌情報 en : JAMA Network Open

巻 2, 号 11, p. e1915819, 発行日 2019-11
ISSN
収録物識別子 2574-3805
PubMed番号
関連識別子
関連識別子 31747035
DOI
関連識別子
関連識別子 10.1001/jamanetworkopen.2019.15819
権利
権利情報 © 2019 ItoM et al.
権利
権利情報 This is an open access article distributed under the terms of the CC-BY License.
著者版フラグ
値 publisher
出版者
出版者 American Medical Association
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