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Widely Impaired White Matter Integrity and Altered Structural Brain Networks in Psychogenic Non-Epileptic Seizures
http://hdl.handle.net/2241/00161386
http://hdl.handle.net/2241/001613866aac6194-aa7f-441e-b56b-ec2153ea0bfa
名前 / ファイル | ライセンス | アクション |
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NDT_15-3549 (3.4 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2020-09-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Widely Impaired White Matter Integrity and Altered Structural Brain Networks in Psychogenic Non-Epileptic Seizures | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
太田, 深秀
× 太田, 深秀× Sone, Daichi× Sato, Noriko× Kimura, Yukio× Matsuda, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: The underlying neural correlates of psychogenic non-epileptic seizures (PNES) are still unknown and their identification would be helpful for clinicians and patients. This study aimed to reveal details of white matter microstructure and alterations in brain structural networks in patients with PNES by using diffusion tensor imaging (DTI) and graph theoretical connectivity analysis. Methods: Seventeen patients with PNES and 26 age- and sex-matched healthy controls were enrolled. All participants underwent DTI on a 3.0-T MRI scanner, and fractional anisotropy (FA) and mean diffusivity (MD) maps were compared by tract-based spatial statistics. Additionally, the structural networks derived from DTI data were analyzed using graph theory and two different parcellation schemes. Results: Patients with PNES showed widespread decreases in FA and increases in MD, particularly in the deep white matter. In addition, graph theoretical analysis revealed impaired brain networks in PNES, including increased path length, decreased network efficiency, altered nodal topology, and reduced regional connectivity in the right posterior areas. Conclusion: We found widely impaired white matter integrity and impaired brain structural networks in Japanese patients with PNES. These findings contribute to the accumulation of evidence on PNES and may improve understanding of this condition. |
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書誌情報 |
en : Neuropsychiatric Disease and Treatment 巻 15, p. 3549-3555, 発行日 2019-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1178-2021 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12157821 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 31920315 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2147/NDT.S235159 | |||||
権利 | ||||||
権利情報 | © 2019 Sone et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Dove Medical Press |