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Brain morphological and functional features in cognitive subgroups of schizophrenia
http://hdl.handle.net/2241/00161378
http://hdl.handle.net/2241/001613786375c9f0-1f85-417b-b1ee-8d2499cb8920
名前 / ファイル | ライセンス | アクション |
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PCN_74-3 (791.7 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2020-09-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Brain morphological and functional features in cognitive subgroups of schizophrenia | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
根本, 清貴
× 根本, 清貴× Yasuda, Yuka× Okada, Naohiro× Fukunaga, Masaki× Yamamori, Hidenaga× Ohi, Kazutaka× Koshiyama, Daisuke× Kudo, Noriko× Shiino, Tomoko× Morita, Susumu× Morita, Kentaro× Azechi, Hirotsugu× Fujimoto, Michiko× Miura, Kenichiro× Watanabe, Yoshiyuki× Kasai, Kiyoto× Hashimoto, Ryota |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aim Previous studies have reported different brain morphologies in different cognitive subgroups of patients with schizophrenia. We aimed to examine the brain structures and functional connectivity in these cognitive subgroups of schizophrenia. Methods We compared brain structures among healthy controls and cognitively deteriorated and preserved subgroups of patients with schizophrenia according to the decline in IQ. Connectivity analyses between subcortical regions and other brain areas were performed using resting‐state functional magnetic resonance imaging among the groups. Results Whole brain and total cortical gray matter, right fusiform gyrus, left pars orbitalis gyrus, right pars triangularis, left superior temporal gyrus and left insula volumes, and bilateral cortical thickness were decreased in the deteriorated group compared to the control and preserved groups. Both schizophrenia subgroups had increased left lateral ventricle, right putamen and left pallidum, and decreased bilateral hippocampus, left precentral gyrus, right rostral middle frontal gyrus, and bilateral superior frontal gyrus volumes compared with controls. Hyperconnectivity between the thalamus and a broad range of brain regions was observed in the deteriorated group compared to connectivity in the control group, and this hyperconnectivity was less evident in the preserved group. We also found hyperconnectivity between the accumbens and the superior and middle frontal gyri in the preserved group compared with connectivity in the deteriorated group. Conclusion These findings provide evidence of prominent structural and functional brain abnormalities in deteriorated patients with schizophrenia, suggesting that cognitive subgroups in schizophrenia might be useful biotypes to elucidate brain pathophysiology for new diagnostic and treatment strategies. |
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書誌情報 |
en : Psychiatry and clinical neurosciences 巻 74, 号 3, p. 191-203, 発行日 2020-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1323-1316 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11040669 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 31793131 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/pcn.12963 | |||||
権利 | ||||||
権利情報 | © 2019 The Authors | |||||
権利 | ||||||
権利情報 | Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology | |||||
権利 | ||||||
権利情報 | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Wiley |