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Resveratrol and its dimers ε‐viniferin and δ‐viniferin in red wine protect vascular endothelial cells by a similar mechanism with different potency and efficacy
http://hdl.handle.net/2241/00161166
http://hdl.handle.net/2241/00161166153558a8-01d9-428e-91df-cb79b9eb6f8f
名前 / ファイル | ライセンス | アクション |
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KJMS_36-7 (2.0 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2020-09-04 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Resveratrol and its dimers ε‐viniferin and δ‐viniferin in red wine protect vascular endothelial cells by a similar mechanism with different potency and efficacy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
吉田, 滋樹
× 吉田, 滋樹× 宮崎, 均× Wu, Che Wei× Nakamoto, Yoshihiro× Hisatome, Takumaru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Red wine compounds have been reported to reduce the rate of atherosclerosis by inducing nitric oxide (NO) production and antioxidant enzyme expression in vascular endothelial cells (VECs). The present study compared the effects of the three red wine compounds resveratrol and its dimers, ε‐viniferin and δ‐viniferin, on VECs function for the first time. Both 5 μM ε‐viniferin and δ‐viniferin, but not 5 μM resveratrol, significantly stimulated wound repair of VECs. Increased levels of wound repair induced by 10 and 20 μM ε‐viniferin were significantly higher than those stimulated by 10 and 20 μM resveratrol, respectively. These stimulatory effects of the three compounds were suppressed by the NO synthase inhibitor L‐NAME. When VECs were exposed to each compound, endothelial NO synthase was activated and the expression of sirtuin 1 (SIRT1) and HO‐1 was induced. Addition of the SIRT1 and HO‐1 inhibitors EX527 and ZnPPiX, respectively, suppressed wound repair stimulated by the three compounds, demonstrating that SIRT1 and HO‐1 are involved in these wound repair processes. Furthermore, each compound induced the suppression of H2O2‐dependent reduction of cell viability as well as the expression of the antioxidant enzyme catalase. These data suggest that not only resveratrol, but also its dimers, ε‐viniferin and δ‐viniferin, may be effective in preventing atherosclerosis by a similar molecular mechanism with different potency and efficacy. | |||||
書誌情報 |
en : Kaohsiung journal of medical sciences 巻 36, 号 7, p. 535-542, 発行日 2020-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1607-551X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11083413 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 32118360 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/kjm2.12199 | |||||
権利 | ||||||
権利情報 | © 2020 The Authors. The Kaohsiung Journal of Medical Sciences published by John Wiley & Sons Australia on behalf of Kaohsiung Medical University. | |||||
権利 | ||||||
権利情報 | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Wiley |