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Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis
http://hdl.handle.net/2241/00160224
http://hdl.handle.net/2241/00160224823d76aa-cfc0-4418-9267-d83dd9ab078a
名前 / ファイル | ライセンス | アクション |
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Angiogenesis_23 (6.2 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2020-06-26 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
濱田, 理人
× 濱田, 理人× 高橋, 智× Dieterich, Lothar C.× Tacconi, Carlotta× Menzi, Franziska× Proulx, Steven T.× Kapaklikaya, Kübra× Detmar, Michael |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | MAFB is a transcription factor involved in the terminal differentiation of several cell types, including macrophages and keratinocytes. MAFB is also expressed in lymphatic endothelial cells (LECs) and is upregulated by VEGF-C/VEGFR-3 signaling. Recent studies have revealed that MAFB regulates several genes involved in lymphatic differentiation and that global Mafb knockout mice show defects in patterning of lymphatic vessels during embryogenesis. However, it has remained unknown whether this effect is LEC-intrinsic and whether MAFB might also be involved in postnatal lymphangiogenesis. We established conditional, lymphatic-specific Mafb knockout mice and found comparable lymphatic patterning defects during embryogenesis as in the global MAFB knockout. Lymphatic MAFB deficiency resulted in increased lymphatic branching in the diaphragm at P7, but had no major effect on lymphatic patterning or function in healthy adult mice. By contrast, tumor-induced lymphangiogenesis was enhanced in mice lacking lymphatic MAFB. Together, these data reveal that LEC-expressed MAFB is involved in lymphatic vascular morphogenesis during embryonic and postnatal development as well as in pathological conditions. Therefore, MAFB could represent a target for therapeutic modulation of lymphangiogenesis. | |||||
書誌情報 |
en : Angiogenesis 巻 23, 号 3, p. 411-423, 発行日 2020-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0969-6970 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11692229 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 32307629 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10456-020-09721-1 | |||||
権利 | ||||||
権利情報 | © The Author(s) 2020 | |||||
権利 | ||||||
権利情報 | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creat iveco mmons .org/licen ses/by/4.0/. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Springer |