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Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors
http://hdl.handle.net/2241/00160174
http://hdl.handle.net/2241/0016017448efb42b-b2c1-48bb-970d-f66cc9fe87bd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CR_29-7-2001.pdf (6.3 MB)
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| Item type | Journal Article(1) | |||||
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| 公開日 | 2020-06-19 | |||||
| タイトル | ||||||
| タイトル | Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
山田, 朋子
× 山田, 朋子× Majidi, Shahriyar P.× Reddy, Naveen C.× Moore, Michael J.× Chen, Hao× Andzelm, Milena M.× Cherry, Timothy J.× Hu, Linda S.× Greenberg, Michael E.× Bonni, Azad |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Compensation among paralogous transcription factors (TFs) confers genetic robustness of cellular processes, but how TFs dynamically respond to paralog depletion on a genome-wide scale in vivo remains incompletely understood. Using single and double conditional knockout of myocyte enhancer factor 2 (MEF2) family TFs in granule neurons of the mouse cerebellum, we find that MEF2A and MEF2D play functionally redundant roles in cerebellar-dependent motor learning. Although both TFs are highly expressed in granule neurons, transcriptomic analyses show MEF2D is the predominant genomic regulator of gene expression in vivo. Strikingly, genome-wide occupancy analyses reveal upon depletion of MEF2D, MEF2A occupancy robustly increases at a subset of sites normally bound to MEF2D. Importantly, sites experiencing compensatory MEF2A occupancy are concentrated within open chromatin and undergo functional compensation for genomic activation and gene expression. Finally, motor activity induces a switch from non-compensatory to compensatory MEF2-dependent gene regulation. These studies uncover genome-wide functional interdependency between paralogous TFs in the brain. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Cell Reports 巻 29, 号 7, p. 2001-2015.e5, 発行日 2019-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 2211-1247 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.celrep.2019.10.033 | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31722213 | |||||
| 権利情報 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2019 The Authors. | |||||
| 権利情報 | ||||||
| 言語 | en | |||||
| 権利情報 | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | Cell Press | |||||
| 言語 | en | |||||
