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Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium
http://hdl.handle.net/2241/00159645
9f8d7d1d-fbcc-4990-9bbc-424f36b4029f
名前 / ファイル | ライセンス | Actions | |
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item type | Journal Article(1) | |||||
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公開日 | 2020-02-21 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
タイプ | journal article | |||||
著者 |
石井, 幸雄
× 石井, 幸雄× 森島, 祐子× 高橋, 智× 檜澤, 伸之× Matsuyama, Masashi× Sakurai, Hirofumi× Ano, Satoshi× Yoh, Keigyou× Ogawa, Kenji |
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抄録 | ||||||
内容記述 | Mycobacterium avium complex (MAC) is the most common cause of nontuberculous mycobacterial disease in humans. The role of Th17 immunity in the pathogenesis of intracellular bacteria, such as MAC, is not currently understood. Transcription factor RAR-related orphan receptor gamma t (RORγt) is known as the master regulator for Th17 cell development. Here, we investigated the role of RORγt in host responses against MAC infection. Wild-type (WT) mice and RORγt-overexpressing mice were infected with MAC via intratracheal inoculation. Systemic MAC growth was not different between WT mice and RORγt-overexpressing mice. However, neutrophilic pulmonary inflammation following MAC infection was enhanced in RORγt-overexpressing mice compared with that in WT mice. The cytokine expression shifted toward a Th17 phenotype in the lungs of RORγt-overexpressing mice following MAC infection; the levels of IL-6 and IL-17 were significantly higher in the lung of these mice than in WT mice. In addition to the increase in IL-17 single-positive T cells, T cells producing both IL-17 and interferon-γ were elevated in the lung of RORγt-overexpressing mice following MAC infection. These findings suggest that RORγt overexpression-mediated Th17 bias contributes to local inflammation rather than systemic responses, by regulating neutrophil recruitment into the sites of infection during MAC infection. | |||||
書誌情報 |
en : PLOS ONE 巻 11, 号 1, p. e0147064, 発行日 2016-01 |
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ISSN | ||||||
収録物識別子 | 1932-6203 | |||||
PubMed番号 | ||||||
関連識別子 | ||||||
関連識別子 | 26784959 | |||||
DOI | ||||||
関連識別子 | ||||||
関連識別子 | 10.1371/journal.pone.0147064 | |||||
権利 | ||||||
権利情報 | © 2016 Matsuyama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Public Library of Science |