{"_buckets": {"deposit": "27437346-6e58-4db7-a317-4f060db566af"}, "_deposit": {"id": "53591", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "53591"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00053591"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "2246", "bibliographicPageStart": "2237", "bibliographicVolumeNumber": "110", "bibliographic_titles": [{"bibliographic_title": "Cancer science"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Glycoprotein NMB (GPNMB) is highly expressed in many types of malignant tumors and thought to be a poor prognostic factor in those cancers, including breast cancer. Glycoprotein NMB is a type IA transmembrane protein that has a long extracellular domain (ECD) and a short intracellular domain (ICD). In general, the ECD of a protein is involved in protein\u2010protein or protein\u2010carbohydrate interactions, whereas the ICD is important for intracellular signaling. We previously reported that GPNMB contributes to the initiation and malignant progression of breast cancer through the hemi\u2010immunoreceptor tyrosine\u2010based activation motif (hemITAM) in its ICD. Furthermore, we showed that the tyrosine residue in hemITAM is involved in induction of the stem\u2010like properties of breast cancer cells. However, the contribution of the ECD to its tumorigenic function has yet to be fully elucidated. In this study, we focused on the region, the so\u2010called kringle\u2010like domain (KLD), that is conserved among species, and made a deletion mutant, GPNMB(\u0394KLD). Enhanced expression of WT GPNMB induced sphere and tumor formation in breast epithelial cells; in contrast, GPNMB(\u0394KLD) lacked these activities without affecting its molecular properties, such as subcellular localization, Src\u2010induced tyrosine phosphorylation at least in overexpression experiments, and homo\u2010oligomerization. Additionally, GPNMB(\u0394KLD) lost its cell migration promoting activity, even though it reduced E\u2010cadherin expression. Although the interaction partner binding to KLD has not yet been identified, we found that the KLD of GPNMB plays an important role in its tumorigenic potential.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "wiley"}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "31127873", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1111/cas.14076", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "This is an open access article under the terms of theCreat ive Commo ns Attri butio n\u2010NonCo mmercialLicense, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. \u00a9 2019 The Authors. Cancer Science published by John Wiley \u0026 Sons Australia, Ltd on behalf of Japanese Cancer Association."}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1347-9032", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11808050", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NII\u30b5\u30d6\u30b8\u30a7\u30af\u30c8", "attribute_value_mlt": [{"subitem_subject": "\u533b\u5b66", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6c96\u7530, \u7d50\u82b1\u91cc"}, {"creatorName": "\u30aa\u30ad\u30bf, \u30e6\u30ab\u30ea", "creatorNameLang": "ja-Kana"}, {"creatorName": "OKITA, Yukari", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "204103", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30743710", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000030743710"}, {"nameIdentifier": "0000004030", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000004030"}]}, {"creatorNames": [{"creatorName": "\u52a0\u85e4, \u5149\u4fdd"}, {"creatorName": "\u30ab\u30c8\u30a6, \u30df\u30c4\u30e4\u30b9", "creatorNameLang": "ja-Kana"}, {"creatorName": "KATO, Mitsuyasu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "611", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "20194855", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000020194855"}, {"nameIdentifier": "0000001657", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001657"}]}, {"creatorNames": [{"creatorName": "Xie, Rudy", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "216577", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichikawa, Yumu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "216578", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fikry, Muhammad Ali", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "216579", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Huynh Dam, Kim Tuyen", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "216580", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tran, Sophie Thi PhuongDung", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "216581", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-11-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CS_110-7.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_9", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "CS_110-7", "url": "https://tsukuba.repo.nii.ac.jp/record/53591/files/CS_110-7.pdf"}, "version_id": "0b68a19e-2335-4c72-90de-a498f5ad72ce"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Role of the kringle\u2010like domain in glycoprotein NMB for its tumorigenic potential", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Role of the kringle\u2010like domain in glycoprotein NMB for its tumorigenic potential"}]}, "item_type_id": "5", "owner": "1", "path": ["2780/7760", "2780/918", "3/62/5298/1032"], "permalink_uri": "http://hdl.handle.net/2241/00159009", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2019-11-28"}, "publish_date": "2019-11-28", "publish_status": "0", "recid": "53591", "relation": {}, "relation_version_is_last": true, "title": ["Role of the kringle\u2010like domain in glycoprotein NMB for its tumorigenic potential"], "weko_shared_id": 5}