{"_buckets": {"deposit": "33d1a535-7d3d-4856-ae6c-7011aa8352f7"}, "_deposit": {"id": "52170", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "52170"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00052170"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-02", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "1638", "bibliographicVolumeNumber": "9", "bibliographic_titles": [{}, {"bibliographic_title": "Scientific Reports", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Photodynamic therapy (PDT) is a cancer treatment that make use of the cancer-specific accumulation of porphyrins. We have reported that mitochondrial reactive oxygen species (mitROS) upregulate uptake transporter of porphyrins, heme carrier protein-1 (HCP-1). The accumulation of cancer-specific porphyrins was increased by mitROS production, thereby the cancer-specific PDT cytotoxicity was enhanced. Thus we investigated whether mitROS production by hyperthermia can enhanced the cytotoxicity of PDT or not. In this study, 1\u2009h of hyperthermia at 42\u2009\u00b0C increased the mitROS production, and both the accumulation of cancer-specific porphyrins and the PDT cytotoxicity increased. Moreover, the authors treated cells with N-acetyl-L-cysteine (NAC) to examine the effect of mitROS. NAC inhibited the increasing ROS production after hyperthermia to restrain the post-treatment increase of cancer-specific porphyrins accumulation. Moreover, the increase of ROS production in cancer cells after hyperthermia upregulated HCP-1 expression and downregulated ABCG2 expression. These regulation were inhibited by NAC. These results suggest that hyperthermia treatment increased mitROS production, which involved HpD accumulation and enhanced PDT effects in cancer cells. The mechanism of this phenomenon was most likely to be due to both the upregulation of HCP-1 and the downregulation of ABCG2 by mitROS.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nature "}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "30733583", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/s41598-018-38460-z", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 The Author(s) 2019"}, {"subitem_rights": "This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article\u2019s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article\u2019s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/."}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u677e\u4e95, \u88d5\u53f2"}, {"creatorName": "\u30de\u30c4\u30a4, \u30d2\u30ed\u30d5\u30df", "creatorNameLang": "ja-Kana"}, {"creatorName": "MATSUI, Hirofumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106737", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70272200", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000070272200"}, {"nameIdentifier": "0000001752", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001752"}]}, {"creatorNames": [{"creatorName": "Kurokawa, Hiromi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214364", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Hiromu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214365", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Terasaki, Masahiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "214366", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-27"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "SR_9-1-1638.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "SR_9-1638", "url": "https://tsukuba.repo.nii.ac.jp/record/52170/files/SR_9-1-1638.pdf"}, "version_id": "cec3fcb3-ff22-42db-aa7f-dd251d0a2c38"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Hyperthermia enhances photodynamic therapy by regulation of HCP1 and ABCG2 expressions via high level ROS generation", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Hyperthermia enhances photodynamic therapy by regulation of HCP1 and ABCG2 expressions via high level ROS generation", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "1", "path": ["2780/2196", "3/62/5601/1884"], "permalink_uri": "http://hdl.handle.net/2241/00157598", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2019-08-27"}, "publish_date": "2019-08-27", "publish_status": "0", "recid": "52170", "relation": {}, "relation_version_is_last": true, "title": ["Hyperthermia enhances photodynamic therapy by regulation of HCP1 and ABCG2 expressions via high level ROS generation"], "weko_shared_id": 5}