{"_buckets": {"deposit": "c8604191-5213-46a3-a150-4ba0c14c39fe"}, "_deposit": {"id": "52160", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "52160"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00052160"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageStart": "e13972", "bibliographicVolumeNumber": "7", "bibliographic_titles": [{"bibliographic_title": "Physiological Reports"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Exercise can improve morbidity and mortality in heart failure patients; however, the underlying mechanisms remain to be fully investigated. Thus, we investigated the effects of exercise on cardiac function and ventricular arrhythmias in myocardial infarction (MI) induced heart failure mice. Wild\u2010type male mice underwent sham\u2010operation or permanent left coronary artery ligation to induce MI. MI mice were divided into a sedentary (MI\u2010Sed) and two intervention groups: MI\u2010Ex (underwent 6\u2010week treadmill exercise training) and MI\u2010\u03b2b (oral bisoprolol treatment (1 mg/kg/d) without exercise). Cardiac function and structure were assessed by echocardiography and histology. Exercise capacity and cardiopulmonary function was accepted as oxygen consumption at peak exercise (peak VO2). Autonomic nervous system function and the incidence of spontaneous ventricular arrhythmia were evaluated via telemetry recording. mRNA and protein expressions in the left ventricle (LV) were investigated by real\u2010time PCR and Western blotting. There were no differences in survival rate, MI size, cardiac function and structure, while exercise training improved peak VO2. Compared with MI\u2010Sed, MI\u2010Ex, and MI\u2010\u03b2b showed decreased sympathetic tone and lower incidence of spontaneous ventricular arrhythmia. By Western blot, the hyperphosphorylation of CaMKII and RyR2 were restored by exercise and \u03b2\u2010blocker treatment. Furthermore, elevated expression of miR\u20101 and decreased expression of its target protein PP2A were recovered by exercise and \u03b2\u2010blocker treatment. Continuous intensive exercise training can suppress ventricular arrhythmias in subacute to chronic phase of MI through restoring autonomic imbalance and impaired calcium handling, similarly to that for \u03b2\u2010blockers.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Wiley"}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "30806037", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.14814/phy2.13972", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a92019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2051817X", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6751\u8d8a, \u4f38\u884c"}, {"creatorName": "\u30e0\u30e9\u30b3\u30b7, \u30ce\u30d6\u30e6\u30ad", "creatorNameLang": "ja-Kana"}, {"creatorName": "MURAKOSHI, Nobuyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "108189", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80447218", "nameIdentifierScheme": "e-Rad", 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