ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To

Field does not validate



インデックスリンク

インデックスツリー

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "8676ab47-56fb-4014-bc8c-05bac5a96516"}, "_deposit": {"id": "51789", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "51789"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00051789"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-11", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "892", "bibliographicVolumeNumber": "12", "bibliographic_titles": [{}, {"bibliographic_title": "Frontiers in Neuroscience", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Neurons expressing neuropeptide orexins (hypocretins) in the lateral hypothalamus (LH) and serotonergic neurons in the dorsal raphe nucleus (DR) both play important roles in the regulation of sleep/wakefulness states, and show similar firing patterns across sleep/wakefulness states. Orexin neurons send excitatory projections to serotonergic neurons in the DR, which express both subtypes of orexin receptors (Mieda et al., 2011), while serotonin (5-HT) potently inhibits orexin neurons through activation of 5HT1A receptors (5HT1ARs). In this study, we examined the physiological importance of serotonergic inhibitory regulation of orexin neurons by studying the phenotypes of mice lacking the 5HT1A receptor gene (Htr1a) specifically in orexin neurons (ox5HT1ARKO mice). ox5HT1ARKO mice exhibited longer NREM sleep time along with decreased wakefulness time in the later phase of the dark period. We also found that restraint stress induced a larger impact on REM sleep architecture in ox5HT1ARKO mice than in controls, with a larger delayed increase in REM sleep amount as compared with that in controls, indicating abnormality of REM sleep homeostasis in the mutants. These results suggest that 5HT1ARs in orexin neurons are essential in the regulation of sleep/wakefulness states, and that serotonergic regulation of orexin neurons plays a crucial role in the appropriate control of orexinergic tone to maintain normal sleep/wake architecture.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Frontiers "}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "30555297", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3389/fnins.2018.00892", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2018 Saito, Tsujino, Abe, Yamazaki, Sakimura and Sakurai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. "}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1662-453X", "subitem_source_identifier_type": "ISSN"}]}, "item_5_subject_20": {"attribute_name": "NII\u30b5\u30d6\u30b8\u30a7\u30af\u30c8", "attribute_value_mlt": [{"subitem_subject": "\u533b\u5b66", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6afb\u4e95, \u6b66"}, {"creatorName": "\u30b5\u30af\u30e9\u30a4, \u30bf\u30b1\u30b7", "creatorNameLang": "ja-Kana"}, {"creatorName": "SAKURAI, Takeshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "157113", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "60251055", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000060251055"}, {"nameIdentifier": "0000001592", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001592"}]}, {"creatorNames": [{"creatorName": "Saito, Yuki C.", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "212897", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsujino, Natsuko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "212898", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Abe, Manabu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "212899", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamazaki, Maya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "212900", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakimura, Kenji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "212901", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-26"}], "displaytype": "detail", "download_preview_message": "", "filename": "FN_12-892.pdf", "filesize": [{"value": "5.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 56000000, "url": {"label": "FN_12-892", "url": "https://tsukuba.repo.nii.ac.jp/record/51789/files/FN_12-892.pdf"}, "version_id": "7f61aff3-471b-4323-8efb-8d63f89460cb"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "1", "path": ["2780/5540", "3/62/5588/5746"], "permalink_uri": "http://hdl.handle.net/2241/00157218", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2019-07-26"}, "publish_date": "2019-07-26", "publish_status": "0", "recid": "51789", "relation": {}, "relation_version_is_last": true, "title": ["Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture"], "weko_shared_id": 5}
  1. 医学医療系 (Faculty of Medicine)
  2. 櫻井 武 (Sakurai Takeshi)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. F~
  4. Frontiers in neuroscience

Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture

http://hdl.handle.net/2241/00157218
9053a30d-2486-4822-b592-bf85bb21d020
プレビュー
名前 / ファイル ライセンス Actions
FN_12-892.pdf FN_12-892 (5.6 MB)
license.icon
item type Journal Article(1)
公開日 2019-07-26
タイトル
言語 en
タイトル Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture
言語
言語 eng
資源タイプ
タイプ journal article
著者 櫻井, 武

× 櫻井, 武

WEKO 157113
e-Rad 60251055
筑波大学研究者総覧 0000001592

櫻井, 武

ja-Kana サクライ, タケシ

en SAKURAI, Takeshi

Search repository
Saito, Yuki C.

× Saito, Yuki C.

WEKO 212897

en Saito, Yuki C.

Search repository
Tsujino, Natsuko

× Tsujino, Natsuko

WEKO 212898

en Tsujino, Natsuko

Search repository
Abe, Manabu

× Abe, Manabu

WEKO 212899

en Abe, Manabu

Search repository
Yamazaki, Maya

× Yamazaki, Maya

WEKO 212900

en Yamazaki, Maya

Search repository
Sakimura, Kenji

× Sakimura, Kenji

WEKO 212901

en Sakimura, Kenji

Search repository
抄録
内容記述 Neurons expressing neuropeptide orexins (hypocretins) in the lateral hypothalamus (LH) and serotonergic neurons in the dorsal raphe nucleus (DR) both play important roles in the regulation of sleep/wakefulness states, and show similar firing patterns across sleep/wakefulness states. Orexin neurons send excitatory projections to serotonergic neurons in the DR, which express both subtypes of orexin receptors (Mieda et al., 2011), while serotonin (5-HT) potently inhibits orexin neurons through activation of 5HT1A receptors (5HT1ARs). In this study, we examined the physiological importance of serotonergic inhibitory regulation of orexin neurons by studying the phenotypes of mice lacking the 5HT1A receptor gene (Htr1a) specifically in orexin neurons (ox5HT1ARKO mice). ox5HT1ARKO mice exhibited longer NREM sleep time along with decreased wakefulness time in the later phase of the dark period. We also found that restraint stress induced a larger impact on REM sleep architecture in ox5HT1ARKO mice than in controls, with a larger delayed increase in REM sleep amount as compared with that in controls, indicating abnormality of REM sleep homeostasis in the mutants. These results suggest that 5HT1ARs in orexin neurons are essential in the regulation of sleep/wakefulness states, and that serotonergic regulation of orexin neurons plays a crucial role in the appropriate control of orexinergic tone to maintain normal sleep/wake architecture.
書誌情報 en : Frontiers in Neuroscience

巻 12, p. 892, 発行日 2018-11
ISSN
収録物識別子 1662-453X
PubMed番号
関連識別子
関連識別子 30555297
DOI
関連識別子
関連識別子 10.3389/fnins.2018.00892
権利
権利情報 © 2018 Saito, Tsujino, Abe, Yamazaki, Sakimura and Sakurai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
著者版フラグ
値 publisher
出版者
出版者 Frontiers
Back
0
views
See details
Views

Versions

Ver.1 2021-03-01 16:59:08.265830
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio