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  1. 生命環境系 (Faculty of Life and Environmental Sciences)
  2. 萩原 大祐 (Hagiwara Daisuke)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. E~
  4. Emerging infectious diseases

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

http://hdl.handle.net/2241/00157182
54af1ef9-1d5e-4c30-b838-c966efe26376
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名前 / ファイル ライセンス Actions
EID_24-10.pdf EID_24-10 (2.8 MB)
item type Journal Article(1)
公開日 2019-07-25
タイトル
言語 en
タイトル Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase
言語
言語 eng
資源タイプ
タイプ journal article
著者 萩原, 大祐

× 萩原, 大祐

WEKO 204657
e-Rad 20612203
筑波大学研究者総覧 0000004047

萩原, 大祐

ja-Kana ハギワラ, ダイスケ

en Hagiwara, Daisuke

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Arai, Teppei

× Arai, Teppei

WEKO 212734

en Arai, Teppei

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Takahashi, Hiroki

× Takahashi, Hiroki

WEKO 212735

en Takahashi, Hiroki

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Kusuya, Yoko

× Kusuya, Yoko

WEKO 212736

en Kusuya, Yoko

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Watanabe, Akira

× Watanabe, Akira

WEKO 212737

en Watanabe, Akira

Search repository
Kamei, Katsuhiko

× Kamei, Katsuhiko

WEKO 212738

en Kamei, Katsuhiko

Search repository
抄録
内容記述 The recent increase in azole-resistant Aspergillus fumigatus is a global concern. Identifying the mutations that confer azole resistance is essential for developing novel methods for prompt diagnosis and effective drug treatment. We screened A. fumigatus clinical isolates for novel mutations conferring azole resistance. We compared the genomic sequences of susceptible and resistant isolates without mutations in cyp51A (non-cyp51A) and found mutations in hmg1 and erg6 involved in ergosterol biosynthesis. We also found the novel mutations in these genes in azole-resistant isolates with different genetic backgrounds. The resistant isolates with mutations in hmg1 showed increased intracellular ergosterol levels compared with susceptible isolates. This finding supports the concept that the ergosterol level is a determinant for resistance to any class of azoles. Multiple isolates with increased resistance to azole possessed a mutation in hmg1, indicating that this mutation is widely present in non-cyp51A azole-resistant A. fumigatus.
書誌情報 en : Emerging Infectious Diseases

巻 24, 号 10, p. 1889-1897, 発行日 2018-10
ISSN
収録物識別子 1080-6040
書誌レコードID
収録物識別子 AA11211604
PubMed番号
関連識別子
関連識別子 30226177
DOI
関連識別子
関連識別子 10.3201/eid2410.180730
著者版フラグ
値 publisher
出版者
出版者 Centers for Disease Control and Prevention
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