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Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase
http://hdl.handle.net/2241/00157182
54af1ef9-1d5e-4c30-b838-c966efe26376
名前 / ファイル | ライセンス | Actions | |
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item type | Journal Article(1) | |||||||||||
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公開日 | 2019-07-25 | |||||||||||
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言語 | en | |||||||||||
タイトル | Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
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タイプ | journal article | |||||||||||
著者 |
萩原, 大祐
× 萩原, 大祐
WEKO
204657
× Arai, Teppei× Takahashi, Hiroki× Kusuya, Yoko× Watanabe, Akira× Kamei, Katsuhiko |
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抄録 | ||||||||||||
内容記述 | The recent increase in azole-resistant Aspergillus fumigatus is a global concern. Identifying the mutations that confer azole resistance is essential for developing novel methods for prompt diagnosis and effective drug treatment. We screened A. fumigatus clinical isolates for novel mutations conferring azole resistance. We compared the genomic sequences of susceptible and resistant isolates without mutations in cyp51A (non-cyp51A) and found mutations in hmg1 and erg6 involved in ergosterol biosynthesis. We also found the novel mutations in these genes in azole-resistant isolates with different genetic backgrounds. The resistant isolates with mutations in hmg1 showed increased intracellular ergosterol levels compared with susceptible isolates. This finding supports the concept that the ergosterol level is a determinant for resistance to any class of azoles. Multiple isolates with increased resistance to azole possessed a mutation in hmg1, indicating that this mutation is widely present in non-cyp51A azole-resistant A. fumigatus. | |||||||||||
書誌情報 |
en : Emerging Infectious Diseases 巻 24, 号 10, p. 1889-1897, 発行日 2018-10 |
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収録物識別子 | 1080-6040 | |||||||||||
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収録物識別子 | AA11211604 | |||||||||||
PubMed番号 | ||||||||||||
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関連識別子 | 30226177 | |||||||||||
DOI | ||||||||||||
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関連識別子 | 10.3201/eid2410.180730 | |||||||||||
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値 | publisher | |||||||||||
出版者 | ||||||||||||
出版者 | Centers for Disease Control and Prevention |