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  1. 医学医療系 (Faculty of Medicine)
  2. 馬 恩博 (Ma Enbo)
  1. 医学医療系 (Faculty of Medicine)
  2. 山岸 良匡 (Yamagishi Kazumasa)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. J~
  4. Journal of epidemiology

Dietary Antioxidant Micronutrients and All-Cause Mortality: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk

http://hdl.handle.net/2241/00155069
0319ffab-43b6-4d06-bb61-55d79e54b7f4
プレビュー
名前 / ファイル ライセンス Actions
JE_28-9.pdf JE_28-9 (256.7 kB)
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item type Journal Article(1)
公開日 2019-04-12
タイトル
タイトル Dietary Antioxidant Micronutrients and All-Cause Mortality: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk
言語
言語 eng
資源タイプ
タイプ journal article
著者 山岸, 良匡

× 山岸, 良匡

WEKO 44
e-Rad 20375504
筑波大学研究者総覧 0000001615

山岸, 良匡

ja-Kana ヤマギシ, カズマサ

en YAMAGISHI, Kazumasa

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Ma, Enbo

× Ma, Enbo

WEKO 208217

en Ma, Enbo

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Iso, Hiroyasu

× Iso, Hiroyasu

WEKO 208218

en Iso, Hiroyasu

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Ando, Masahiko

× Ando, Masahiko

WEKO 208219

en Ando, Masahiko

Search repository
Wakai, Kenji

× Wakai, Kenji

WEKO 208220

en Wakai, Kenji

Search repository
Tamakoshi, Akiko

× Tamakoshi, Akiko

WEKO 208221

en Tamakoshi, Akiko

Search repository
抄録
内容記述 Background: Oxidative stress, the imbalance between pro- and antioxidants, has been implicated in the etiology and pathophysiology of the incidence and mortality of many diseases. We aim to investigate the relations of dietary intakes of vitamin C and E and main carotenoids with all-cause mortality in Japanese men and women.

Methods: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk had 22,795 men and 35,539 women, aged 40–79 years at baseline (1988–1990), who completed a valid food frequency questionnaire and were followed up to the end of 2009.

Results: There were 6,179 deaths in men and 5,355 deaths in women during the median follow-up of 18.9 years for men and 19.4 years for women. Multivariate hazard ratios for the highest versus lowest quintile intakes in women were 0.83 (95% confidence interval [CI], 0.76–0.90; P for trend < 0.0001) for vitamin C, 0.85 (95% CI, 0.78–0.93; P for trend < 0.0001) for vitamin E, 0.88 (95% CI, 0.81–0.96; P for trend = 0.0006) for β-carotene, and 0.90 (95% CI, 0.82–0.98; P for trend = 0.0002) for β-cryptoxanthin. The joint effect of any two of these highly correlated micronutrients showed significant 12–17% reductions in risk in the high-intake group compared with the low-intake group in women. These significant associations were also observed in the highest quintile intakes of vitamin C, vitamin E, and β-carotene in female non-smokers but were not observed in female smokers, male smokers, and non-smokers.

Conclusions: Higher dietary intakes of antioxidant vitamins may reduce the risk of all-cause mortality in middle-aged Japanese women, especially female non-smokers.
書誌情報 Journal of epidemiology

巻 28, 号 9, p. 388-396, 発行日 2018-09
ISSN
収録物識別子 0917-5040
書誌レコードID
収録物識別子 AA10952696
PubMed番号
関連識別子
関連識別子 29806637
DOI
関連識別子
関連識別子 10.2188/jea.JE20170023
権利
権利情報 © 2018 Enbo Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
著者版フラグ
値 publisher
出版者
出版者 Japan Epidemiological Association
出版者別名
出版者 一般社団法人 日本疫学会
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