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Therapeutic Potential of Patient iPSC-Derived iMelanocytes in Autologous Transplantation
http://hdl.handle.net/2241/00154824
http://hdl.handle.net/2241/0015482400b49e3e-4c1d-47e9-b105-793941cc7480
名前 / ファイル | ライセンス | アクション |
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CR_27-2.pdf (6.1 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2019-03-12 | |||||
タイトル | ||||||
タイトル | Therapeutic Potential of Patient iPSC-Derived iMelanocytes in Autologous Transplantation | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
鄭, 允文
× 鄭, 允文× Liu, Li-Ping× Li, Yu-Mei× Guo, Ning-Ning× Li, Shu× Ma, Xiaolong× Zhang, Yi-Xuan× Gao, Yimeng× Huang, Jian-Ling× Zheng, Dong-Xu× Wang, Lu-Yuan× Xu, Hui× Hui, Lijian |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Induced pluripotent stem cells (iPSCs) are a promising melanocyte source as they propagate indefinitely and can be established from patients. However, the in vivo functions of human iPSC-derived melanocytes (hiMels) remain unknown. Here, we generated hiMels from vitiligo patients using a three-dimensional system with enhanced differentiation efficiency, which showed characteristics of human epidermal melanocytes with high sequence similarity and involved in multiple vitiligo-associated signaling pathways. A modified hair follicle reconstitution assay in vivo showed that MITF+PAX3+TYRP1+ hiMels were localized in the mouse hair bulb and epidermis and produced melanin up to 7 weeks after transplantation, whereas MITF+PAX3+TYRP1? hiMelanocyte stem cells integrated into the bulge-subbulge regions. Overall, these data demonstrate the long-term functions of hiMels in vivo to reconstitute pigmented hair follicles and to integrate into normal regions for both mature melanocytes and melanocyte stem cells, providing an alternative source of personalized cellular therapy for depigmentation. | |||||
言語 | en | |||||
書誌情報 |
en : Cell Reports 巻 27, 号 2, p. 455-466.e5, 発行日 2019-04 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 2211-1247 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.celrep.2019.03.046 | |||||
PMID | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30970249 | |||||
権利情報 | ||||||
言語 | en | |||||
権利情報 | ©2019 The Author(s). | |||||
権利情報 | ||||||
言語 | en | |||||
権利情報 | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Cell Press | |||||
言語 | en |