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  1. 医学医療系 (Faculty of Medicine)
  2. 西山 博之 (Nishiyama Hiroyuki)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. B~
  4. Basic and Clinical Andrology

Relationship between Semenogelins bound to human sperm and other semen parameters and pregnancy outcomes

http://hdl.handle.net/2241/00154788
e905e35c-199f-4ead-a61f-0d3425280df6
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BCA_27-15.pdf BCA_27-15 (399.7 kB)
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item type Journal Article(1)
公開日 2019-03-07
タイトル
タイトル Relationship between Semenogelins bound to human sperm and other semen parameters and pregnancy outcomes
言語
言語 eng
資源タイプ
タイプ journal article
著者 西山, 博之

× 西山, 博之

WEKO 695
e-Rad 20324642
筑波大学研究者総覧 0000003058

西山, 博之

ja-Kana ニシヤマ, ヒロユキ

en NISHIYAMA, Hiroyuki

Search repository
Yamasaki, Kazumitsu

× Yamasaki, Kazumitsu

WEKO 206411

en Yamasaki, Kazumitsu

Search repository
Yoshida, Kaoru

× Yoshida, Kaoru

WEKO 206412

en Yoshida, Kaoru

Search repository
Yoshiike, Miki

× Yoshiike, Miki

WEKO 206413

en Yoshiike, Miki

Search repository
Shimada, Kazuhiko

× Shimada, Kazuhiko

WEKO 206414

en Shimada, Kazuhiko

Search repository
Takamizawa, Satoru

× Takamizawa, Satoru

WEKO 206415

en Takamizawa, Satoru

Search repository
Yanagida, Kaoru

× Yanagida, Kaoru

WEKO 206416

en Yanagida, Kaoru

Search repository
Iwamoto, Teruaki

× Iwamoto, Teruaki

WEKO 206417

en Iwamoto, Teruaki

Search repository
抄録
内容記述 Background
Semenogelins (SEMGs) are major components of human seminal vesicle secretions. Due to SEMG’s sperm-motility inhibitor, a significant negative correlation between sperm motility and the proportion of SEMG-bound spermatozoa (SEMG+) was found in asthenozoospermic patients. SEMGs also show intrinsic inhibitory capability for sperm capacitation; however, studies on actual clinical specimens have not been conducted.

Methods
To reveal the relationship between SEMGs and the fertilizing capacity of sperm from male infertile patients who are not restricted to asthenozoospermia, we measured the proportion of SEMG+ in the spermatozoa of 142 male infertile patients. The pregnancy outcomes in partners of these patients were retrospectively analyzed using questionnaires.

Results
Among examined semen parameters, only the total SEMG-unbound sperm count showed a tendency to be different between the spontaneous pregnancy or intra-uterine-insemination-pregnancy groups and in-vitro-fertilization- or intracytoplasmic-sperm-injection-pregnancy groups. It was elevated in the former group, which includes patients who used in vivo fertilization.

Conclusions
The total SEMG-unbound sperm count would be a relevant parameter for in vivo fertilization. This result suggests that SEMGs inhibit ectopic capacitation before sperm reach the fertilization site and that the number of total SEMG-unbound sperm is a parameter directly linked to the possibility of in vivo fertilization.
書誌情報 Basic and Clinical Andrology

巻 27, 号 15, 発行日 2017-08
ISSN
収録物識別子 2051-4190
DOI
関連識別子
関連識別子 10.1186/s12610-017-0059-6
権利
権利情報 © The Author(s). 2017Open Access
権利
権利情報 This article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise state
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出版者 BMC
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