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Due to SEMG\u2019s sperm-motility inhibitor, a significant negative correlation between sperm motility and the proportion of SEMG-bound spermatozoa (SEMG+) was found in asthenozoospermic patients. SEMGs also show intrinsic inhibitory capability for sperm capacitation; however, studies on actual clinical specimens have not been conducted.\n\nMethods\nTo reveal the relationship between SEMGs and the fertilizing capacity of sperm from male infertile patients who are not restricted to asthenozoospermia, we measured the proportion of SEMG+ in the spermatozoa of 142 male infertile patients. The pregnancy outcomes in partners of these patients were retrospectively analyzed using questionnaires.\n\nResults\nAmong examined semen parameters, only the total SEMG-unbound sperm count showed a tendency to be different between the spontaneous pregnancy or intra-uterine-insemination-pregnancy groups and in-vitro-fertilization- or intracytoplasmic-sperm-injection-pregnancy groups. It was elevated in the former group, which includes patients who used in vivo fertilization.\n\nConclusions\nThe total SEMG-unbound sperm count would be a relevant parameter for in vivo fertilization. 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Relationship between Semenogelins bound to human sperm and other semen parameters and pregnancy outcomes
http://hdl.handle.net/2241/00154788
e905e35c-199f-4ead-a61f-0d3425280df6
名前 / ファイル | ライセンス | Actions | |
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item type | Journal Article(1) | |||||||||||
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公開日 | 2019-03-07 | |||||||||||
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タイトル | Relationship between Semenogelins bound to human sperm and other semen parameters and pregnancy outcomes | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
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タイプ | journal article | |||||||||||
著者 |
西山, 博之
× 西山, 博之
WEKO
695
× Yamasaki, Kazumitsu× Yoshida, Kaoru× Yoshiike, Miki× Shimada, Kazuhiko× Takamizawa, Satoru× Yanagida, Kaoru× Iwamoto, Teruaki |
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抄録 | ||||||||||||
内容記述 | Background Semenogelins (SEMGs) are major components of human seminal vesicle secretions. Due to SEMG’s sperm-motility inhibitor, a significant negative correlation between sperm motility and the proportion of SEMG-bound spermatozoa (SEMG+) was found in asthenozoospermic patients. SEMGs also show intrinsic inhibitory capability for sperm capacitation; however, studies on actual clinical specimens have not been conducted. Methods To reveal the relationship between SEMGs and the fertilizing capacity of sperm from male infertile patients who are not restricted to asthenozoospermia, we measured the proportion of SEMG+ in the spermatozoa of 142 male infertile patients. The pregnancy outcomes in partners of these patients were retrospectively analyzed using questionnaires. Results Among examined semen parameters, only the total SEMG-unbound sperm count showed a tendency to be different between the spontaneous pregnancy or intra-uterine-insemination-pregnancy groups and in-vitro-fertilization- or intracytoplasmic-sperm-injection-pregnancy groups. It was elevated in the former group, which includes patients who used in vivo fertilization. Conclusions The total SEMG-unbound sperm count would be a relevant parameter for in vivo fertilization. This result suggests that SEMGs inhibit ectopic capacitation before sperm reach the fertilization site and that the number of total SEMG-unbound sperm is a parameter directly linked to the possibility of in vivo fertilization. |
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書誌情報 |
Basic and Clinical Andrology 巻 27, 号 15, 発行日 2017-08 |
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収録物識別子 | 2051-4190 | |||||||||||
DOI | ||||||||||||
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関連識別子 | 10.1186/s12610-017-0059-6 | |||||||||||
権利 | ||||||||||||
権利情報 | © The Author(s). 2017Open Access | |||||||||||
権利 | ||||||||||||
権利情報 | This article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise state | |||||||||||
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値 | publisher | |||||||||||
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出版者 | BMC |