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Myosin Id localizes in dendritic spines through the tail homology 1 domain
http://hdl.handle.net/2241/00152547
http://hdl.handle.net/2241/00152547d1189c2b-33b6-4183-ab34-d6f362fb79a3
名前 / ファイル | ライセンス | アクション |
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ECR_367-1 (9.4 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-07-12 | |||||
タイトル | ||||||
タイトル | Myosin Id localizes in dendritic spines through the tail homology 1 domain | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Koshida, Ryusuke
× Koshida, Ryusuke× Tome, Saki× Takei, Yosuke |
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著者別名 |
越田, 隆介
× 越田, 隆介× 武井, 陽介 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dendritic spines, the postsynaptic compartments at excitatory synapses, are capable of changing their shape and size to modulate synaptic transmission. The actin cytoskeleton and a variety of actin-binding proteins play a critical role in the dynamics of dendritic spines. Class I myosins are monomeric motor proteins that move along actin filaments using the energy of ATP hydrolysis. Of these class I myosins, myosin Id, the mammalian homolog of Drosophila Myo31DF, has been reported to be expressed in neurons, whereas its subcellular localization in neurons remained unknown. Here, we investigated the subcellular localization of myosin Id and determined the domain responsible for it. We found that myosin Id is enriched in the F-actin-rich pseudopodia of HEK293T cells and in the dendritic spines of primary hippocampal neurons. Both deletion and substitution of the tail homology 1 (TH1) domain drastically diminishes its colocalization with F-actin. In addition, the mutant form lacking the TH1 domain is less distributed in dendritic spines than is the full-length form. Taken together, our findings reveal that myosin Id localizes in dendritic spines through the TH1 domain. | |||||
書誌情報 |
Experimental cell research 巻 367, 号 1, p. 65-72, 発行日 2018-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0014-4827 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00641011 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29559226 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.yexcr.2018.03.021 | |||||
権利 | ||||||
権利情報 | © 2018 Elsevier Inc. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier Inc. |