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  1. 医学医療系 (Faculty of Medicine)
  2. 松井 裕史 (Matsui Hirofumi)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. J~
  4. Journal of clinical biochemistry and nutrition

Cancer cell-specific mitochondrial reactive oxygen species promote non-heme iron uptake and enhance the proliferation of gastric epithelial cancer cell

http://hdl.handle.net/2241/00150662
4cc59048-9496-4048-b4d9-97c6e4a4cbec
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名前 / ファイル ライセンス Actions
JCBN_61-3-183.pdf JCBN_61-3-183 (428.4 kB)
item type Journal Article(1)
公開日 2018-02-21
タイトル
タイトル Cancer cell-specific mitochondrial reactive oxygen species promote non-heme iron uptake and enhance the proliferation of gastric epithelial cancer cell
言語
言語 eng
資源タイプ
タイプ journal article
著者 Ito, Hiromu

× Ito, Hiromu

WEKO 182358

Ito, Hiromu

Search repository
Kurokawa, Hiromi

× Kurokawa, Hiromi

WEKO 182359

Kurokawa, Hiromi

Search repository
Hirayama, Aki

× Hirayama, Aki

WEKO 182360

Hirayama, Aki

Search repository
P. Indo, Hiroko

× P. Indo, Hiroko

WEKO 182361

P. Indo, Hiroko

Search repository
J. Majima, Hideyuki

× J. Majima, Hideyuki

WEKO 182362

J. Majima, Hideyuki

Search repository
Matsui, Hirofumi

× Matsui, Hirofumi

WEKO 182363

Matsui, Hirofumi

Search repository
著者別名 松井, 裕史

× 松井, 裕史

WEKO 106737
e-Rad 70272200
筑波大学研究者総覧 0000001752

松井, 裕史

Search repository
抄録
内容記述 Iron is an essential nutrient for life and is involved in many important processes such as oxygen transport and DNA synthesis. However, excess amounts of iron can cause carcinogenesis by producing reactive oxygen species. Thus, the cellular transport of iron must be tightly regulated. In the human body, iron may be present as heme or non-heme iron. The mechanisms governing the cellular transport of these forms have not been clearly elucidated. We previously reported that the expression of an important heme transporter, heme carrier protein 1 was regulated by cancer-specific reactive oxygen species derived from mitochondria. In this study, we have asked if mitochondrial reactive oxygen species may also be related with non-heme iron transport. In order to address this question, we have investigated the relationship between mitochondrial reactive oxygen species and accumulation of cellular non-heme iron in a rat gastric normal, cancer and manganese superoxide dismutase-overexpressing cancer cell line, in which reactive oxygen species from mitochondria are specifically scavenged. We have also analyzed the expression of divalent metal transporter 1 and ferroprotin, involved in the incorporation and excretion of non-heme iron, respectively, as well as a hypoxia-related transcription factor HIF-1α, to elucidate the molecular mechanism of non-heme iron accumulation.
書誌情報 Journal of clinical biochemistry and nutrition

巻 61, 号 3, p. 183-188, 発行日 2017-11
ISSN
収録物識別子 0912-0009
書誌レコードID
収録物識別子 AA10710201
PubMed番号
関連識別子
関連識別子 29203959
DOI
関連識別子
関連識別子 10.3164/jcbn.17-8
権利
権利情報 ©2017 JCBN
著者版フラグ
値 publisher
出版者
出版者 Society for Free Radical Research Japan
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