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Cancer cell-specific mitochondrial reactive oxygen species promote non-heme iron uptake and enhance the proliferation of gastric epithelial cancer cell
http://hdl.handle.net/2241/00150662
4cc59048-9496-4048-b4d9-97c6e4a4cbec
名前 / ファイル | ライセンス | Actions | |
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item type | Journal Article(1) | |||||
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公開日 | 2018-02-21 | |||||
タイトル | ||||||
タイトル | Cancer cell-specific mitochondrial reactive oxygen species promote non-heme iron uptake and enhance the proliferation of gastric epithelial cancer cell | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
タイプ | journal article | |||||
著者 |
Ito, Hiromu
× Ito, Hiromu× Kurokawa, Hiromi× Hirayama, Aki× P. Indo, Hiroko× J. Majima, Hideyuki× Matsui, Hirofumi |
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著者別名 |
松井, 裕史
× 松井, 裕史 |
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抄録 | ||||||
内容記述 | Iron is an essential nutrient for life and is involved in many important processes such as oxygen transport and DNA synthesis. However, excess amounts of iron can cause carcinogenesis by producing reactive oxygen species. Thus, the cellular transport of iron must be tightly regulated. In the human body, iron may be present as heme or non-heme iron. The mechanisms governing the cellular transport of these forms have not been clearly elucidated. We previously reported that the expression of an important heme transporter, heme carrier protein 1 was regulated by cancer-specific reactive oxygen species derived from mitochondria. In this study, we have asked if mitochondrial reactive oxygen species may also be related with non-heme iron transport. In order to address this question, we have investigated the relationship between mitochondrial reactive oxygen species and accumulation of cellular non-heme iron in a rat gastric normal, cancer and manganese superoxide dismutase-overexpressing cancer cell line, in which reactive oxygen species from mitochondria are specifically scavenged. We have also analyzed the expression of divalent metal transporter 1 and ferroprotin, involved in the incorporation and excretion of non-heme iron, respectively, as well as a hypoxia-related transcription factor HIF-1α, to elucidate the molecular mechanism of non-heme iron accumulation. | |||||
書誌情報 |
Journal of clinical biochemistry and nutrition 巻 61, 号 3, p. 183-188, 発行日 2017-11 |
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ISSN | ||||||
収録物識別子 | 0912-0009 | |||||
書誌レコードID | ||||||
収録物識別子 | AA10710201 | |||||
PubMed番号 | ||||||
関連識別子 | ||||||
関連識別子 | 29203959 | |||||
DOI | ||||||
関連識別子 | ||||||
関連識別子 | 10.3164/jcbn.17-8 | |||||
権利 | ||||||
権利情報 | ©2017 JCBN | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Society for Free Radical Research Japan |