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The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses
http://hdl.handle.net/2241/00148413
http://hdl.handle.net/2241/00148413b6cbf2ae-8f18-40f9-a19b-353e84cd9f07
名前 / ファイル | ライセンス | アクション |
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Item type | Journal Article(1) | |||||||||||
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公開日 | 2017-10-05 | |||||||||||
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タイトル | The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
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資源タイプ | journal article | |||||||||||
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アクセス権 | open access | |||||||||||
著者 |
Takahama, Michihiro
× Takahama, Michihiro× Fukuda, Mitsunori× 大林, 典彦
WEKO
151461
× Kozaki, Tatsuya× Misawa, Takuma× Okamoto, Toru× Matsuura, Yoshiharu× Akira, Shizuo× Saitoh, Tatsuya |
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内容記述 | Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces the IFN antiviral response. However, the regulatory mechanisms that mediate cGAS-triggered signaling have not been fully explored. Here, we show the involvement of a small GTPase, RAB2B, and its effector protein, Golgi-associated RAB2B interactor-like 5 (GARIL5), in the cGAS-mediated IFN response. RAB2B-deficiency affects the IFN response induced by cytosolic DNA. Consistent with this, RAB2B deficiency enhances replication of vaccinia virus, a DNA virus. After DNA stimulation, RAB2B colocalizes with stimulator of interferon genes (STING), the downstream signal mediator of cGAS, on the Golgi apparatus. The GTP-binding activity of RAB2B is required for its localization on the Golgi apparatus and for recruitment of GARIL5. GARIL5 deficiency also affects the IFN response induced by cytosolic DNA and enhances replication of vaccinia virus. These findings indicate that the RAB2B-GARIL5 complex promotes IFN responses against DNA viruses by regulating the cGAS-STING signaling axis. | |||||||||||
書誌情報 |
en : Cell Reports 巻 20, 号 12, p. 2944-2954, 発行日 2017-09 |
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収録物識別子タイプ | PISSN | |||||||||||
収録物識別子 | 2211-1247 | |||||||||||
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関連タイプ | isIdenticalTo | |||||||||||
関連識別子 | https://doi.org/10.1016/j.celrep.2017.08.085 | |||||||||||
PMID | ||||||||||||
関連識別子 | 28930687 | |||||||||||
権利情報 | ||||||||||||
権利情報 | © 2017 The Author(s). | |||||||||||
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権利情報 | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||||||||
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出版タイプ | VoR | |||||||||||
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出版者 | Cell Press |