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  1. 医学医療系 (Faculty of Medicine)
  2. 三島 初 (Mishima Hajime)
  1. 医学医療系 (Faculty of Medicine)
  2. 山崎 正志 (Yamazaki Masashi)
  1. 医学医療系 (Faculty of Medicine)
  2. 菅谷 久 (Sugaya Hisashi)
  1. 医学医療系 (Faculty of Medicine)
  2. 吉岡 友和 (Yoshioka Tomokazu)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. B~
  4. Bone Marrow Research

Feasibility and Efficacy of Autologous Bone Marrow Aspirate Transplantation Combined with Human Parathyroid Hormone 1-34 Administration to Treat Osteonecrosis in a Rabbit Model

http://hdl.handle.net/2241/00145801
f2b717d2-6414-4320-94ff-c427e519d673
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BMR_2017-2484689.pdf BMR_2017-2484689 (5.3 MB)
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item type Journal Article(1)
公開日 2017-04-12
タイトル
タイトル Feasibility and Efficacy of Autologous Bone Marrow Aspirate Transplantation Combined with Human Parathyroid Hormone 1-34 Administration to Treat Osteonecrosis in a Rabbit Model
言語
言語 eng
資源タイプ
タイプ journal article
著者 Makihara, Takeshi

× Makihara, Takeshi

WEKO 160112

Makihara, Takeshi

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Yoshioka, Tomokazu

× Yoshioka, Tomokazu

WEKO 160113

Yoshioka, Tomokazu

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Sugaya, Hisashi

× Sugaya, Hisashi

WEKO 160114

Sugaya, Hisashi

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Aoto, Katsuya

× Aoto, Katsuya

WEKO 160115

Aoto, Katsuya

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Wada, Hiroshi

× Wada, Hiroshi

WEKO 160116

Wada, Hiroshi

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Uemura, Kenta

× Uemura, Kenta

WEKO 160117

Uemura, Kenta

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Tanaka, Kenta

× Tanaka, Kenta

WEKO 160118

Tanaka, Kenta

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Akaogi, Hiroshi

× Akaogi, Hiroshi

WEKO 160119

Akaogi, Hiroshi

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Yamazaki, Masashi

× Yamazaki, Masashi

WEKO 160120

Yamazaki, Masashi

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Mishima, Hajime

× Mishima, Hajime

WEKO 160121

Mishima, Hajime

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著者別名 吉岡, 友和

× 吉岡, 友和

WEKO 160122

吉岡, 友和

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菅谷, 久

× 菅谷, 久

WEKO 204420
e-Rad 10752553
筑波大学研究者総覧 0000003676

菅谷, 久

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山崎, 正志

× 山崎, 正志

WEKO 204981
e-Rad 50281712
筑波大学研究者総覧 0000003338

山崎, 正志

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三島, 初

× 三島, 初

WEKO 204881
e-Rad 60361341
筑波大学研究者総覧 0000001800

三島, 初

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抄録
内容記述 No studies have examined the transplantation of a bone marrow aspirate (BMA) containing mesenchymal stem cells (MSCs) combined with human parathyroid hormone 1-34 (hPTH1-34) administration. Therefore, we evaluated the feasibility and efficacy of autologous BMA transplantation combined with hPHT1-34 administration in a bone necrosis model. The metatarsal bones of rabbits were necrotized using liquid nitrogen, and the rabbits received a BMA transplantation or saline injection followed by hPTH1-34 (30 μg/kg) or saline administration three times per week ( = 3-4 per group). The rabbits were euthanized at 12 weeks after the initiation of treatment. No systemic adverse effects or local neoplastic lesions were observed. Importantly, the rabbits in the BMA transplantation plus hPTH1-34 group showed the highest bone volumes and histological scores of new bone. These data confirmed the feasibility of BMA transplantation combined with hPTH1-34, at least during the experimental period. The observed efficacy may be explained by a synergistic effect from the stimulation of MSC differentiation to osteoblasts with hPTH1-34-mediated suppression of apoptosis in osteoblasts. These results indicate the promising potential for BMA transplantation combined with hPTH1-34 administration in bone necrosis treatment. Longer term experiments are needed to confirm the safety of this therapeutic strategy.
書誌情報 Bone Marrow Research

巻 2017, p. 2484689, 発行日 2017-03
ISSN
収録物識別子 2090-2999
PubMed番号
関連識別子
関連識別子 28386485
DOI
関連識別子
関連識別子 10.1155/2017/2484689
権利
権利情報 © 2017 Takeshi Makihara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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出版者
出版者 Hindawi
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