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Feasibility and Efficacy of Autologous Bone Marrow Aspirate Transplantation Combined with Human Parathyroid Hormone 1-34 Administration to Treat Osteonecrosis in a Rabbit Model
http://hdl.handle.net/2241/00145801
f2b717d2-6414-4320-94ff-c427e519d673
名前 / ファイル | ライセンス | Actions | |
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item type | Journal Article(1) | |||||
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公開日 | 2017-04-12 | |||||
タイトル | ||||||
タイトル | Feasibility and Efficacy of Autologous Bone Marrow Aspirate Transplantation Combined with Human Parathyroid Hormone 1-34 Administration to Treat Osteonecrosis in a Rabbit Model | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
タイプ | journal article | |||||
著者 |
Makihara, Takeshi
× Makihara, Takeshi× Yoshioka, Tomokazu× Sugaya, Hisashi× Aoto, Katsuya× Wada, Hiroshi× Uemura, Kenta× Tanaka, Kenta× Akaogi, Hiroshi× Yamazaki, Masashi× Mishima, Hajime |
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著者別名 |
吉岡, 友和
× 吉岡, 友和× 菅谷, 久× 山崎, 正志× 三島, 初 |
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抄録 | ||||||
内容記述 | No studies have examined the transplantation of a bone marrow aspirate (BMA) containing mesenchymal stem cells (MSCs) combined with human parathyroid hormone 1-34 (hPTH1-34) administration. Therefore, we evaluated the feasibility and efficacy of autologous BMA transplantation combined with hPHT1-34 administration in a bone necrosis model. The metatarsal bones of rabbits were necrotized using liquid nitrogen, and the rabbits received a BMA transplantation or saline injection followed by hPTH1-34 (30 μg/kg) or saline administration three times per week ( = 3-4 per group). The rabbits were euthanized at 12 weeks after the initiation of treatment. No systemic adverse effects or local neoplastic lesions were observed. Importantly, the rabbits in the BMA transplantation plus hPTH1-34 group showed the highest bone volumes and histological scores of new bone. These data confirmed the feasibility of BMA transplantation combined with hPTH1-34, at least during the experimental period. The observed efficacy may be explained by a synergistic effect from the stimulation of MSC differentiation to osteoblasts with hPTH1-34-mediated suppression of apoptosis in osteoblasts. These results indicate the promising potential for BMA transplantation combined with hPTH1-34 administration in bone necrosis treatment. Longer term experiments are needed to confirm the safety of this therapeutic strategy. | |||||
書誌情報 |
Bone Marrow Research 巻 2017, p. 2484689, 発行日 2017-03 |
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ISSN | ||||||
収録物識別子 | 2090-2999 | |||||
PubMed番号 | ||||||
関連識別子 | ||||||
関連識別子 | 28386485 | |||||
DOI | ||||||
関連識別子 | ||||||
関連識別子 | 10.1155/2017/2484689 | |||||
権利 | ||||||
権利情報 | © 2017 Takeshi Makihara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Hindawi |