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mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety
http://hdl.handle.net/2241/00145138
http://hdl.handle.net/2241/0014513851963fe4-a494-4b87-925b-b0ab9ff7b052
名前 / ファイル | ライセンス | アクション |
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CR_17-9 (4.5 MB)
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Item type | Journal Article(1) | |||||||||||
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公開日 | 2017-01-31 | |||||||||||
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タイトル | mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety | |||||||||||
言語 | en | |||||||||||
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言語 | eng | |||||||||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | journal article | |||||||||||
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アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
著者 |
Deguchi, Yuichi
× Deguchi, Yuichi× Harada, Masaya× Shinohara, Ryota× ラザルス, ミハエル
WEKO
106747
× Cherasse, Yoan× 裏出 , 良博× Yamada, Daisuke× Sekiguchi, Masayuki× Watanabe, Dai× Furuyashiki, Tomoyuki× Narumiya, Shuh |
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内容記述タイプ | Abstract | |||||||||||
内容記述 | Here, we show neuronal inactivation-induced presynaptic remodeling and involvement of the mammalian homolog of Diaphanous (mDia) and Rho-associated coiled-coil-containing kinase (ROCK), Rho-regulated modulators of actin and myosin, in this process. We find that social isolation induces inactivation of nucleus accumbens (NAc) neurons associated with elevated anxiety-like behavior, and that mDia in NAc neurons is essential in this process. Upon inactivation of cultured neurons, mDia induces circumferential actin filaments around the edge of the synaptic cleft, which contract the presynaptic terminals in a ROCK-dependent manner. Social isolation induces similar mDia-dependent presynaptic contraction at GABAergic synapses from NAc neurons in the ventral tegmental area (VTA) associated with reduced synaptic efficacy. Optogenetic stimulation of NAc neurons rescues the anxiety phenotype, and injection of a specific ROCK inhibitor, Y-27632, into the VTA reverses both presynaptic contraction and the behavioral phenotype. mDia-ROCK signaling thus mediates actin-dependent presynaptic remodeling in inactivated NAc neurons, which underlies synaptic plasticity in emotional behavioral responses. | |||||||||||
言語 | en | |||||||||||
書誌情報 |
en : Cell Reports 巻 17, 号 9, p. 2405-2417, 発行日 2016-11 |
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収録物識別子タイプ | PISSN | |||||||||||
収録物識別子 | 2211-1247 | |||||||||||
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関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | https://doi.org/10.1016/j.celrep.2016.10.088 | |||||||||||
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識別子タイプ | PMID | |||||||||||
関連識別子 | 27880913 | |||||||||||
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言語 | en | |||||||||||
権利情報 | (c) 2016 The Authors | |||||||||||
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言語 | en | |||||||||||
権利情報 | This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org /licenses/by-nc-nd/4.0/ ). | |||||||||||
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出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
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出版者 | Cell Press | |||||||||||
言語 | en |