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Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer
http://hdl.handle.net/2241/00145133
http://hdl.handle.net/2241/00145133f945539f-5bfd-4280-995e-f000525267d6
名前 / ファイル | ライセンス | アクション |
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Item type | Journal Article(1) | |||||
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公開日 | 2017-01-31 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Mani, Ram S.
× Mani, Ram S.× Amin, Mohammad A.× Li, Xiangyi× Kalyana-Sundaram, Shanker× Veeneman, Brendan A.× Wang, Lei× Ghosh, Aparna× Aslam, Adam× Ramanand, Susmita G.× Rabquer, Bradley J.× Kimura, Wataru× Tran, Maxwell× Cao, Xuhong× Roychowdhury, Sameek× Dhanasekaran, Saravana M.× Palanisamy, Nallasivam× Sadek, Hesham A.× Kapur, Payal× Koch, Alisa E.× Chinnaiyan, Arul M. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Approximately 50% of prostate cancers are associated with gene fusions of the androgen-regulated gene TMPRSS2 to the oncogenic erythroblast transformation-specific (ETS) transcription factor ERG. The three-dimensional proximity of TMPRSS2 and ERG genes, in combination with DNA breaks, facilitates the formation of TMPRSS2-ERG gene fusions. However, the origins of DNA breaks that underlie gene fusion formation in prostate cancers are far from clear. We demonstrate a role for inflammation-induced oxidative stress in the formation of DNA breaks leading to recurrent TMPRSS2-ERG gene fusions. The transcriptional status and epigenetic features of the target genes influence this effect. Importantly, inflammation-induced de novo genomic rearrangements are blocked by homologous recombination (HR) and promoted by non-homologous end-joining (NHEJ) pathways. In conjunction with the association of proliferative inflammatory atrophy (PIA) with human prostate cancer, our results support a working model in which recurrent genomic rearrangements induced by inflammatory stimuli lead to the development of prostate cancer.<br/> | |||||
言語 | en | |||||
書誌情報 |
en : Cell Reports 巻 17, 号 10, p. 2620-2631, 発行日 2016-12 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 2211-1247 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.celrep.2016.11.019 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27926866 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | (c) 2016 The Author(s). | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Cell Press |