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Differential induction of type I interferons in macaques by wild-type measles virus alone or with the hemagglutinin protein of the Edmonston vaccine strain
http://hdl.handle.net/2241/00143806
http://hdl.handle.net/2241/001438066c02f51e-7f94-4816-9087-7e3e529b9d5f
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M&I_60-7 (116.0 kB)
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Item type | Journal Article(1) | |||||||||
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公開日 | 2016-09-06 | |||||||||
タイトル | ||||||||||
タイトル | Differential induction of type I interferons in macaques by wild-type measles virus alone or with the hemagglutinin protein of the Edmonston vaccine strain | |||||||||
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言語 | eng | |||||||||
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資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||
タイプ | journal article | |||||||||
著者 |
Van Nguyen, Nguyen
× Van Nguyen, Nguyen× Kato, Sei-ich× Nagata, Kyosuke× Takeuchi, Kaoru |
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著者別名 |
永田, 恭介
× 永田, 恭介
× 竹内, 薫
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Measles vaccines are highly effective and safe; however, the mechanism(s) underlying their attenuation has not been well understood. In this study, type I IFNs (IFN-α and IFN-β) induction in macaques infected with measles virus (MV) strains was examined. Type I IFNs were not induced in macaques infected with wild-type MV. However, IFN-α was sharply induced in most macaques infected with recombinant wild-type MV bearing the hemagglutinin (H) protein of the Edmonston vaccine strain. These results indicate that the H protein of MV vaccine strains may have a role in MV attenuation. | |||||||||
書誌情報 |
Microbiology and immunology 巻 60, 号 7, p. 501-505, 発行日 2016-07 |
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収録物識別子タイプ | ISSN | |||||||||
収録物識別子 | 1348-0421 | |||||||||
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収録物識別子タイプ | NCID | |||||||||
収録物識別子 | AA12022389 | |||||||||
DOI | ||||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | 10.1111/1348-0421.12392 | |||||||||
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識別子タイプ | PMID | |||||||||
関連識別子 | 27278100 | |||||||||
権利 | ||||||||||
権利情報 | © 2016 The Societies and John Wiley & Sons Australia, Ltd | |||||||||
権利 | ||||||||||
権利情報 | This is the peer reviewed version of the following article:Microbiology and Immunology, 60: 501-505, which has been published in final form at 10.1111/1348-0421.12392 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||||||
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値 | author | |||||||||
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出版者 | Wiley |