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Prediction of Therapeutic Effect of Rasburicase on Hyperuricemia Associated with Chemotherapy Based on Theoretical Model
http://hdl.handle.net/2241/00143013
http://hdl.handle.net/2241/0014301356380b80-3a1d-4e45-ba04-661f339a17ad
名前 / ファイル | ライセンス | アクション |
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BPB_39-5 (772.7 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2016-06-28 | |||||
タイトル | ||||||
タイトル | Prediction of Therapeutic Effect of Rasburicase on Hyperuricemia Associated with Chemotherapy Based on Theoretical Model | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kimura, Koji
× Kimura, Koji× Kanehira, Naomi× Takayanagi, Risa× Minohara, Hideto× Homma, Masato× Yamada, Yasuhiko |
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著者別名 |
本間, 真人
× 本間, 真人 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Rasburicase has a strong and fast effect for reducing blood levels of uric acid. However, there have been no reports of theoretical analysis for the rational dose and interval of administration. Thus we constructed a pharmacokinetic and pharmacodynamic model to determine changes in uric acid level after rasburicase administration at various doses and regimens. The time courses of uric acid level predicted using our model were in good agreement with observed data, indicating adequate performance for our model. The therapeutic effects after a single infusion at various rates of generation of uric acid were predicted. The maximum effect was not a large difference, in spite of the generation rate. Then, the therapeutic effects of repeated administrations were predicted. The effect did not change when rasburicase was administered at more than the usual dose. Besides, as the administration interval increased, the difference between minimum and maximum level of uric acid became greater. However, in all doses and regimens, adequate therapeutic effects were obtained. In conclusion, the model was found useful for predicting therapeutic effect of rasburicase and individually determining rational dosage regimen of rasburicase. | |||||
書誌情報 |
Biological & pharmaceutical bulletin 巻 39, 号 5, p. 705-711, 発行日 2016-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0918-6158 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27150142 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.b15-00700 | |||||
権利 | ||||||
権利情報 | © 2016 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Pharmaceutical Society of Japan |