{"_buckets": {"deposit": "fbad2329-dfc3-4e1e-93a7-da0e81c305a2"}, "_deposit": {"id": "37722", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "37722"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00037722"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-02", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "22038", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "Scientific reports"}]}]}, "item_5_creator_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u9ad8\u8c37, \u76f4\u6a39"}], "nameIdentifiers": [{"nameIdentifier": "130564", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "50282322", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000050282322"}, {"nameIdentifier": "0000001328", "nameIdentifierScheme": "\u7b51\u6ce2\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001328"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Nitric oxide (NO) signaling controls various metabolic pathways in bacteria and higher eukaryotes. Cellular enzymes synthesize and detoxify NO; however, a mechanism that controls its cellular homeostasis has not been identified. Here, we found a nitrogen oxide cycle involving nitrate reductase (Nar) and the NO dioxygenase flavohemoglobin (Fhb), that facilitate inter-conversion of nitrate, nitrite, and NO in the actinobacterium Streptomyces coelicolor. This cycle regulates cellular NO levels, bacterial antibiotic production, and morphological differentiation. NO down-regulates Nar and up-regulates Fhb gene expression via the NO-dependent transcriptional factors DevSR and NsrR, respectively, which are involved in the auto-regulation mechanism of intracellular NO levels. Nitrite generated by the NO cycles induces gene expression in neighboring cells, indicating an additional role of the cycle as a producer of a transmittable inter-cellular communication molecule.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group"}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "26912114", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/srep22038", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article\u2019s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/"}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "ISSN"}]}, "item_5_subject_20": {"attribute_name": "NII\u30b5\u30d6\u30b8\u30a7\u30af\u30c8", "attribute_value_mlt": [{"subitem_subject": "\u8fb2\u82b8\u5316\u5b66", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sasaki, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "129818", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oguchi, Haruka"}], "nameIdentifiers": [{"nameIdentifier": "129819", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "129820", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kusama, Shinichiro"}], "nameIdentifiers": [{"nameIdentifier": "129821", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugiura, Ryo"}], "nameIdentifiers": [{"nameIdentifier": "129822", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Moriya, Kenta"}], "nameIdentifiers": [{"nameIdentifier": "129823", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirata, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "129824", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yukioka, Yuriya"}], "nameIdentifiers": [{"nameIdentifier": "129825", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takaya, Naoki"}], "nameIdentifiers": [{"nameIdentifier": "129826", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yajima, Shunsuke"}], "nameIdentifiers": [{"nameIdentifier": "129827", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Shinsaku"}], "nameIdentifiers": [{"nameIdentifier": "129828", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Kiyoshi"}], "nameIdentifiers": [{"nameIdentifier": "129829", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohsawa, Kanju"}], "nameIdentifiers": [{"nameIdentifier": "129830", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikeda, Haruo"}], "nameIdentifiers": [{"nameIdentifier": "129831", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takano, Hideaki"}], "nameIdentifiers": [{"nameIdentifier": "129832", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ueda, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "129833", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shoun, Hirofumi"}], "nameIdentifiers": [{"nameIdentifier": "129834", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-04-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "SR_6-22038.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_6", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "SR_6-22038", "url": "https://tsukuba.repo.nii.ac.jp/record/37722/files/SR_6-22038.pdf"}, "version_id": "9b5d58a7-0001-47b5-b523-b6766f3d7c6f"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Nitrogen oxide cycle regulates nitric oxide levels and bacterial cell signaling", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Nitrogen oxide cycle regulates nitric oxide levels and bacterial cell signaling"}]}, "item_type_id": "5", "owner": "1", "path": ["160/2173", "3/62/5601/1884"], "permalink_uri": "http://hdl.handle.net/2241/00138502", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-04-13"}, "publish_date": "2016-04-13", "publish_status": "0", "recid": "37722", "relation": {}, "relation_version_is_last": true, "title": ["Nitrogen oxide cycle regulates nitric oxide levels and bacterial cell signaling"], "weko_shared_id": 5}