ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To

Field does not validate



インデックスリンク

インデックスツリー

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "a7550c53-49d0-4a27-9e1f-1ceb2f0a1fa7"}, "_deposit": {"id": "36858", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "36858"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00036858"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "156", "bibliographicPageStart": "144", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "Molecular and cellular biology "}]}]}, "item_5_creator_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4ef2\u5cf6, \u7531\u4f73"}], "nameIdentifiers": [{"nameIdentifier": "125806", "nameIdentifierScheme": "WEKO"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Estrogens are effective in the treatment of prostate cancer; however, the effects of estrogens on prostate cancer are enigmatic. In this study, we demonstrated that estrogen (17\u03b2-estradiol [E2]) has biphasic effects on prostate tumor growth. A lower dose of E2 increased tumor growth in mouse xenograft models using DU145 and PC-3 human prostate cancer cells, whereas a higher dose significantly decreased tumor growth. We found that anchorage-independent apoptosis in these cells was inhibited by E2 treatment. Similarly, in vivo angiogenesis was suppressed by E2. Interestingly, these effects of E2 were abolished by knockdown of either estrogen receptor \u03b2 (ER\u03b2) or Kr\u00fcppel-like zinc finger transcription factor 5 (KLF5). \u0399n addition, E2 suppressed KLF5-mediated transcription through ER\u03b2, which inhibits proapoptotic FOXO1 and proangiogenic PDGFA expression. Furthermore, we revealed that a nonagonistic ER ligand GS-1405 inhibited FOXO1 and PDGFA expression through the ER\u03b2-KLF5 pathway and regulated prostate tumor growth without ER\u03b2 transactivation. Therefore, these results suggest that E2 biphasically modulates prostate tumor formation by regulating KLF5-dependent transcription through ER\u03b2 and provide a new strategy for designing ER modulators, which will be able to regulate prostate cancer progression with minimal adverse effects due to ER transactivation.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "American Society for Microbiology"}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "26483416", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1128/MCB.00625-15", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2015, American Society for Microbiology"}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0270-7306", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10620925", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NII\u30b5\u30d6\u30b8\u30a7\u30af\u30c8", "attribute_value_mlt": [{"subitem_subject": "\u533b\u5b66", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakajima, Yuka"}], "nameIdentifiers": [{"nameIdentifier": "125797", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Osakabe, Asami"}], "nameIdentifiers": [{"nameIdentifier": "125798", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Waku, Tsuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "125799", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "125800", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akaogi, Kensuke"}], "nameIdentifiers": [{"nameIdentifier": "125801", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimura, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "125802", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Homma, Yukio"}], "nameIdentifiers": [{"nameIdentifier": "125803", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inoue, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "125804", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanagisawa, Junn"}], "nameIdentifiers": [{"nameIdentifier": "125805", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-08-01"}], "displaytype": "detail", "download_preview_message": "", "filename": "MCB_36-1.pdf", "filesize": [{"value": "2.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 21000000, "url": {"label": "MCB_36-1", "url": "https://tsukuba.repo.nii.ac.jp/record/36858/files/MCB_36-1.pdf"}, "version_id": "1aec36ad-d377-4859-9c8c-9331c0875192"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Estrogen Exhibits a Biphasic Effect on Prostate Tumor Growth through the Estrogen Receptor \u03b2-KLF5 Pathway", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Estrogen Exhibits a Biphasic Effect on Prostate Tumor Growth through the Estrogen Receptor \u03b2-KLF5 Pathway"}]}, "item_type_id": "5", "owner": "1", "path": ["160/2907", "3/62/5595/641"], "permalink_uri": "http://hdl.handle.net/2241/00134889", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2016-02-03"}, "publish_date": "2016-02-03", "publish_status": "0", "recid": "36858", "relation": {}, "relation_version_is_last": true, "title": ["Estrogen Exhibits a Biphasic Effect on Prostate Tumor Growth through the Estrogen Receptor \u03b2-KLF5 Pathway"], "weko_shared_id": 5}
  1. 生命環境系 (Faculty of Life and Environmental Sciences)
  2. 仲島 由佳 (Nakajima Yuka)
  1. コンテンツタイプ (Contents Type)
  2. 雑誌発表論文等 (Journal article, etc.)
  3. M~
  4. Molecular and cellular biology

Estrogen Exhibits a Biphasic Effect on Prostate Tumor Growth through the Estrogen Receptor β-KLF5 Pathway

http://hdl.handle.net/2241/00134889
cb74f934-d96f-4203-8ad8-daf4b49ba7f1
プレビュー
名前 / ファイル ライセンス Actions
MCB_36-1.pdf MCB_36-1 (2.1 MB)
item type Journal Article(1)
公開日 2016-02-03
タイトル
タイトル Estrogen Exhibits a Biphasic Effect on Prostate Tumor Growth through the Estrogen Receptor β-KLF5 Pathway
言語
言語 eng
資源タイプ
タイプ journal article
著者 Nakajima, Yuka

× Nakajima, Yuka

WEKO 125797

Nakajima, Yuka

Search repository
Osakabe, Asami

× Osakabe, Asami

WEKO 125798

Osakabe, Asami

Search repository
Waku, Tsuyoshi

× Waku, Tsuyoshi

WEKO 125799

Waku, Tsuyoshi

Search repository
Suzuki, Takashi

× Suzuki, Takashi

WEKO 125800

Suzuki, Takashi

Search repository
Akaogi, Kensuke

× Akaogi, Kensuke

WEKO 125801

Akaogi, Kensuke

Search repository
Fujimura, Tetsuya

× Fujimura, Tetsuya

WEKO 125802

Fujimura, Tetsuya

Search repository
Homma, Yukio

× Homma, Yukio

WEKO 125803

Homma, Yukio

Search repository
Inoue, Satoshi

× Inoue, Satoshi

WEKO 125804

Inoue, Satoshi

Search repository
Yanagisawa, Junn

× Yanagisawa, Junn

WEKO 125805

Yanagisawa, Junn

Search repository
著者別名 仲島, 由佳

× 仲島, 由佳

WEKO 125806

仲島, 由佳

Search repository
抄録
内容記述 Estrogens are effective in the treatment of prostate cancer; however, the effects of estrogens on prostate cancer are enigmatic. In this study, we demonstrated that estrogen (17β-estradiol [E2]) has biphasic effects on prostate tumor growth. A lower dose of E2 increased tumor growth in mouse xenograft models using DU145 and PC-3 human prostate cancer cells, whereas a higher dose significantly decreased tumor growth. We found that anchorage-independent apoptosis in these cells was inhibited by E2 treatment. Similarly, in vivo angiogenesis was suppressed by E2. Interestingly, these effects of E2 were abolished by knockdown of either estrogen receptor β (ERβ) or Krüppel-like zinc finger transcription factor 5 (KLF5). Ιn addition, E2 suppressed KLF5-mediated transcription through ERβ, which inhibits proapoptotic FOXO1 and proangiogenic PDGFA expression. Furthermore, we revealed that a nonagonistic ER ligand GS-1405 inhibited FOXO1 and PDGFA expression through the ERβ-KLF5 pathway and regulated prostate tumor growth without ERβ transactivation. Therefore, these results suggest that E2 biphasically modulates prostate tumor formation by regulating KLF5-dependent transcription through ERβ and provide a new strategy for designing ER modulators, which will be able to regulate prostate cancer progression with minimal adverse effects due to ER transactivation.
書誌情報 Molecular and cellular biology

巻 36, 号 1, p. 144-156, 発行日 2016-01
ISSN
収録物識別子 0270-7306
書誌レコードID
収録物識別子 AA10620925
PubMed番号
関連識別子
関連識別子 26483416
DOI
関連識別子
関連識別子 10.1128/MCB.00625-15
権利
権利情報 © 2015, American Society for Microbiology
著者版フラグ
値 author
出版者
出版者 American Society for Microbiology
Back
0
views
See details
Views

Versions

Ver.1 2021-03-02 03:49:52.002570
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio