{"_buckets": {"deposit": "a7550c53-49d0-4a27-9e1f-1ceb2f0a1fa7"}, "_deposit": {"id": "36858", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "36858"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00036858"}, "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "156", "bibliographicPageStart": "144", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "Molecular and cellular biology "}]}]}, "item_5_creator_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4ef2\u5cf6, \u7531\u4f73"}], "nameIdentifiers": [{"nameIdentifier": "125806", "nameIdentifierScheme": "WEKO"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Estrogens are effective in the treatment of prostate cancer; however, the effects of estrogens on prostate cancer are enigmatic. In this study, we demonstrated that estrogen (17\u03b2-estradiol [E2]) has biphasic effects on prostate tumor growth. A lower dose of E2 increased tumor growth in mouse xenograft models using DU145 and PC-3 human prostate cancer cells, whereas a higher dose significantly decreased tumor growth. We found that anchorage-independent apoptosis in these cells was inhibited by E2 treatment. Similarly, in vivo angiogenesis was suppressed by E2. Interestingly, these effects of E2 were abolished by knockdown of either estrogen receptor \u03b2 (ER\u03b2) or Kr\u00fcppel-like zinc finger transcription factor 5 (KLF5). \u0399n addition, E2 suppressed KLF5-mediated transcription through ER\u03b2, which inhibits proapoptotic FOXO1 and proangiogenic PDGFA expression. Furthermore, we revealed that a nonagonistic ER ligand GS-1405 inhibited FOXO1 and PDGFA expression through the ER\u03b2-KLF5 pathway and regulated prostate tumor growth without ER\u03b2 transactivation. Therefore, these results suggest that E2 biphasically modulates prostate tumor formation by regulating KLF5-dependent transcription through ER\u03b2 and provide a new strategy for designing ER modulators, which will be able to regulate prostate cancer progression with minimal adverse effects due to ER transactivation.", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "American Society for Microbiology"}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "26483416", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1128/MCB.00625-15", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2015, American Society for Microbiology"}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0270-7306", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10620925", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NII\u30b5\u30d6\u30b8\u30a7\u30af\u30c8", "attribute_value_mlt": [{"subitem_subject": "\u533b\u5b66", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakajima, Yuka"}], "nameIdentifiers": [{"nameIdentifier": "125797", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Osakabe, Asami"}], "nameIdentifiers": [{"nameIdentifier": "125798", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Waku, Tsuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "125799", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "125800", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akaogi, Kensuke"}], "nameIdentifiers": [{"nameIdentifier": "125801", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimura, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "125802", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Homma, Yukio"}], "nameIdentifiers": [{"nameIdentifier": "125803", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inoue, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "125804", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanagisawa, Junn"}], "nameIdentifiers": [{"nameIdentifier": "125805", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-08-01"}], "displaytype": "detail", "download_preview_message": "", "filename": "MCB_36-1.pdf", "filesize": [{"value": "2.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 21000000, "url": {"label": "MCB_36-1", "url": "https://tsukuba.repo.nii.ac.jp/record/36858/files/MCB_36-1.pdf"}, "version_id": "1aec36ad-d377-4859-9c8c-9331c0875192"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Estrogen Exhibits a Biphasic Effect on Prostate Tumor Growth through the Estrogen Receptor \u03b2-KLF5 Pathway", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Estrogen Exhibits a Biphasic Effect on Prostate Tumor Growth through the Estrogen Receptor \u03b2-KLF5 Pathway"}]}, "item_type_id": "5", "owner": "1", "path": ["160/2907", "3/62/5595/641"], "permalink_uri": "http://hdl.handle.net/2241/00134889", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2016-02-03"}, "publish_date": "2016-02-03", "publish_status": "0", "recid": "36858", "relation": {}, "relation_version_is_last": true, "title": ["Estrogen Exhibits a Biphasic Effect on Prostate Tumor Growth through the Estrogen Receptor \u03b2-KLF5 Pathway"], "weko_shared_id": 5}