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Evaluation of pre-hospital administration of adrenaline (epinephrine) by emergency medical services for patients with out of hospital cardiac arrest in Japan: controlled propensity matched retrospective cohort study
http://hdl.handle.net/2241/120851
http://hdl.handle.net/2241/120851908f43e9-008c-482a-8f7b-caf902778b05
名前 / ファイル | ライセンス | アクション |
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BMJ_347.pdf (526.8 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2014-02-21 | |||||
タイトル | ||||||
タイトル | Evaluation of pre-hospital administration of adrenaline (epinephrine) by emergency medical services for patients with out of hospital cardiac arrest in Japan: controlled propensity matched retrospective cohort study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Nakahara, Shinji
× Nakahara, Shinji× Tomio, Jun× Takahashi, Hideto× Ichikawa, Masao× Nishida, Masamichi× Morimura, Naoto× Sakamoto, Tetsuya |
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著者別名 |
高橋, 秀人
× 高橋, 秀人× 市川, 政雄 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives To evaluate the effectiveness of pre-hospital adrenaline (epinephrine) administered by emergency medical services to patients with out of hospital cardiac arrest. Design Controlled propensity matched retrospective cohort study, in which pairs of patients with or without (control) adrenaline were created with a sequential risk set matching based on time dependent propensity score. Setting Japan’s nationwide registry database of patients with out of hospital cardiac arrest registered between January 2007 and December 2010. Participants Among patients aged 15-94 with out of hospital cardiac arrest witnessed by a bystander, we created 1990 pairs of patients with and without adrenaline with an initial rhythm of ventricular fibrillation or pulseless ventricular tachycardia (VF/VT) and 9058 pairs among those with non-VF/VT. Main outcome measures Overall and neurologically intact survival at one month or at discharge, whichever was earlier. Results After propensity matching, pre-hospital administration of adrenaline by emergency medical services was associated with a higher proportion of overall survival (17.0% v 13.4%; unadjusted odds ratio 1.34, 95% confidence interval 1.12 to 1.60) but not with neurologically intact survival (6.6% v 6.6%; 1.01, 0.78 to 1.30) among those with VF/VT; and higher proportions of overall survival (4.0% v 2.4%; odds ratio 1.72, 1.45 to 2.04) and neurologically intact survival (0.7% v 0.4%; 1.57, 1.04 to 2.37) among those with non-VF/VT. Conclusions Pre-hospital administration of adrenaline by emergency medical services improves the long term outcome in patients with out of hospital cardiac arrest, although the absolute increase of neurologically intact survival was minimal. |
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書誌情報 |
BMJ : British medical journal 巻 347, p. f6829, 発行日 2013-12 |
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PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 24326886 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1136/bmj.f6829 | |||||
権利 | ||||||
権利情報 | This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | BMJ Publishing Group | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/120851 | |||||
識別子タイプ | HDL |