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Association of ADRB2 polymorphism with triglyceride levels in Tongans
http://hdl.handle.net/2241/119663
http://hdl.handle.net/2241/1196632ce4ba56-7e22-4c6f-9c83-30f9944daaa5
名前 / ファイル | ライセンス | アクション |
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LHD_12.pdf (415.3 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2013-09-09 | |||||
タイトル | ||||||
タイトル | Association of ADRB2 polymorphism with triglyceride levels in Tongans | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Naka, Izumi
× Naka, Izumi× Ohashi, Jun× Kimura, Ryosuke× Inaoka, Tsukasa× Matsumura, Yasuhiro |
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著者別名 |
大橋, 順
× 大橋, 順 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background Our previous study demonstrated that the A-allele of the single nucleotide polymorphism (SNP) rs34623097 located in the upstream region of the β2 adrenergic receptor gene (ADRB2) is significantly associated with risk for obesity in Oceanic populations. Methods To investigate whether the ADRB2 polymorphisms explain part of the individual differences in lipid mobilization, energy expenditure and glycogen breakdown, the associations of 10 ADRB2 SNPs with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride levels were examined in 128 adults in Tonga. Results A multiple linear regression analysis adjusted for age, sex, and body mass index revealed that rs34623097 was significantly associated with triglyceride levels (P-value = 0.037). A copy of the rs34623097-A allele increased serum triglyceride levels by 70.1 mg/dL (0.791 mmol/L). None of the ADRB2 SNPs showed a significant association with total-cholesterol, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol. Conclusions In a Tongan population, a SNP located in the upstream region of ADRB2 is associated with triglyceride levels independent of body mass index. |
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書誌情報 |
Lipids in health and disease 巻 12, p. 110, 発行日 2013-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1476-511X | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 23875540 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/1476-511X-12-110 | |||||
権利 | ||||||
権利情報 | © 2013 Naka et al.; licensee BioMed Central Ltd. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | BioMed Central | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/119663 | |||||
識別子タイプ | HDL |