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Pharmacokinetics of core-polymerized, boron-conjugated micelles designed for boron neutron capture therapy for cancer
http://hdl.handle.net/2241/116985
http://hdl.handle.net/2241/116985103db690-c9ac-4999-841f-e64a0fd32ef7
名前 / ファイル | ライセンス | アクション |
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BIOMAT_33-13.pdf (1.1 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2012-05-08 | |||||
タイトル | ||||||
タイトル | Pharmacokinetics of core-polymerized, boron-conjugated micelles designed for boron neutron capture therapy for cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Sumitani, Shogo
× Sumitani, Shogo× Oishi, Motoi× Yaguchi, Tatsuya× Murotani, Hiroki× Horiguchi, Yukichi× Suzuki, Minoru× Ono, Koji× Yanagie, Hironobu× Nagasaki, Yukio |
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著者別名 |
大石, 基
× 大石, 基× 長崎, 幸夫 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Core-polymerized and boron-conjugated micelles (PM micelles) were prepared by free radical copolymerization of a PEG-b-PLA block copolymer bearing an acetal group and a methacryloyl group (acetal-PEG-b-PLA-MA), with 1-(4-vinylbenzyl)-closo-carborane (VB-carborane), and the utility of these micelles as a tumor-targeted boron delivery system was investigated for boron neutron capture therapy (BNCT). Non-polymerized micelles (NPM micelles) that incorporated VB-carborane physically showed significant leakage of VB-carborane (ca. 50%) after 12 h incubation with 10% fetal bovine serum (FBS) at 37 °C. On the other hand, no leakage from the PM micelles was observed even after 48 h of incubation. To clarify the pharmacokinetics of the micelles, 125I (radioisotope)-labeled PM and NPM micelles were administered to colon-26 tumor-bearing BALB/c mice. The 125I-labeled PM micelles showed prolonged blood circulation (area under the concentration curve (AUC): 943.4) than the 125I-labeled NPM micelles (AUC: 495.1), whereas tumor accumulation was similar for both types of micelles (AUCPM micelle: 249.6, AUCNPM micelle: 201.1). In contrast, the tumor accumulation of boron species in the PM micelles (AUC: 268.6) was 7-fold higher than the NPM micelles (AUC: 37.1), determined by ICP-AES. Thermal neutron irradiation yielded tumor growth suppression in the tumor-bearing mice treated with the PM micelles without reduction in body weight. On the basis of these data, the PM micelles represent a promising approach to the creation of boron carrier for BNCT. | |||||
書誌情報 |
Biomaterials 巻 33, 号 13, p. 3568-3577, 発行日 2012-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0142-9612 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00110092 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 22326646 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.biomaterials.2012.01.039 | |||||
権利 | ||||||
権利情報 | © 2012 Elsevier Ltd. NOTICE: this is the author's version of a work that was accepted for publication in Biomaterials. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biomaterials, Volume 33 Issue 13 2012. Doi:10.1016/j.biomaterials.2012.01.039. |
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著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/116985 | |||||
識別子タイプ | HDL |